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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

The optimal cutoff level of D-dimer during pregnancy to exclude deep vein thrombosis, and the association between D-dimer and postpartum hemorrhage in Cesarean section patients

http://hdl.handle.net/10232/00030889
http://hdl.handle.net/10232/00030889
1698b271-7714-46e9-97e3-1315e9c0a9d6
名前 / ファイル ライセンス アクション
Diss_折田_有史_ISK533_2019.pdf Diss_折田_有史_ISK533_2019 (781.6 kB)
Abstract_折田_有史_4512800161_2019.pdf Abstract_折田_有史_4512800161_2019 (146.7 kB)
Result_Orita_Yuji_isk_533.pdf Result_Orita_Yuji_isk_533 (508.7 kB)
Comments_Orita_Yuji_isk_533.pdf Comments_Orita_Yuji_isk_533 (233.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-03-13
タイトル
タイトル The optimal cutoff level of D-dimer during pregnancy to exclude deep vein thrombosis, and the association between D-dimer and postpartum hemorrhage in Cesarean section patients
別言語のタイトル
その他のタイトル 帝王切開術前の深部静脈血栓症に対するD-dimerのカットオフ値およびD-dimerと帝王切開術中出血量の関与についての検討
著者 折田, 有史

× 折田, 有史

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折田, 有史

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著者よみ
姓名 オリタ, ユウジ
別言語の著者
姓名 ORITA, Yuji
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 D-dimer
キーワード
主題言語 en
主題Scheme Other
主題 deep vein thrombosis
キーワード
主題言語 en
主題Scheme Other
主題 cutoff level
キーワード
主題言語 en
主題Scheme Other
主題 singleton
キーワード
主題言語 en
主題Scheme Other
主題 twin pregnancies
キーワード
主題言語 en
主題Scheme Other
主題 postpartum hemorrhage
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Objective: The main purpose was to clarify the optimal D-dimer cutoff level during pregnancy to exclude deep vein thrombosis (DVT) prior to Cesarean section. The secondary purpose was to determine whether D-dimer can predict severe postpartum hemorrhage (PPH) in Cesarean section patients.
Methods: Two hundred and seventy eight elective Cesarean section cases were enrolled. Clinical factors and blood parameters at 34-37 weeks of gestation were analyzed. To detect DVT, lower extremities veins were examined using color Doppler ultrasonography in cases with D-dimer level >_ 1.5 μg/mL. In addition, postpartum blood loss amounts
during Cesarean section were recorded.
Results: Five DVT cases occurred in 250 singleton pregnancies, and 2 DVT cases occurred in 28 twin pregnancies. The overall incidence of DVT was 2.5%. The D-dimer level was higher in DVT cases than in non-DVT cases (3.84±1.97 vs. 2.31±1.48 μg/mL, P<0.01). The optimal D-dimer cutoff level was 2.6 μg/mL with a negative predictive value of 99.5%, and sensitivity of 85.7%. PPH during Cesarean section was positively correlated with D-dimer level in all pregnancies. However, this relationship disappeared after excluding twin pregnancies.
Conclusion: A D-dimer level < 2.6 μg/mL at 34-37 weeks of gestation has the potential to exclude DVT. D-dimer can be an independent predictor for severe PPH for all Cesarean section cases, including twin pregnancies.
要約(Abstract)
内容記述タイプ Other
内容記述 YUJI ORITA, TOMONORI HAMADA, SHINICHI TOGAMI, TSUTOMU DOUCHI, HIROAKI KOBAYASHI
The Optimal Cutoff Level of D-Dimer during Pregnancy to Exclude Deep Vein Thrombosis, and the Association between D-Dimer and Postpartum Hemorrhage in Cesarean Section Patients
The Kurume Medical Journal (2019) 66(2) 107-114
https://doi.org/10.2739/kurumemedj.MS662003
作成日
日付 2020-01-14
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 Kurume University School of Medicine
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:小林裕明】
date.appl
【学位申請日】2019-10-02
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2019-10-02
学位授与番号
学位授与番号 甲総研第533号
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