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末梢単核白血球の血小板活性化因子受容体(PAFR)遺伝子発現変化と糖尿病性腎症の進展との関連
http://hdl.handle.net/10232/00030890
http://hdl.handle.net/10232/0003089088d576c4-9e23-47cb-8b35-1725042ab6ee
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-13 | |||||
| タイトル | ||||||
| タイトル | Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 末梢単核白血球の血小板活性化因子受容体(PAFR)遺伝子発現変化と糖尿病性腎症の進展との関連 | |||||
| 言語 | ja | |||||
| 著者 |
Ghavidel Darestani, Sahar
× Ghavidel Darestani, Sahar |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約(Abstract) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Introduction: Several studies have recently pointed out the role of many inflammatory mediators in the progression of diabetes complications. We had previously demonstrated that mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells (PBMCs) was associated with urinary albumin to creatinine ratio (ACR) and forearm flow-mediated dilatation in patients with type 2 diabetes. In an attempt to elucidate this association, patients were followed up for 1 year. Materials and Methods: We recruited 95 patients from the hospital outpatient clinic, among whom 86 were followed up for 1 year (normoalbuminuria: 40 patients, microalbuminuria: 25 patients, macroalbuminuria: 21 patients). We then measured their baseline and 12 month characteristics and collected blood samples to extract PBMCs and measure gene expressions. Results: Despite higher mRNA expression of PAFR in PBMCs among patients with macroalbuminuria, the rise in its value was not associated with biomarkers of nephropathy, while baseline values were not associated with progression of nephropathy. Moreover, changes in mRNA expression of PAFR were correlated with changes in ACR in all patients (r = 0.225, p = 0.037) and estimated glomerular filtration rate in patients with macroalbuminuria (r = −0.438, p = 0.047) during the follow-up period. Conclusion: Our findings indicate that even though no causal relationship exists between diabetic nephropathy and elevated expression of PAFR in PBMCs, their close association; signifies the presence of another common mechanism that could induce both events. Given these findings, the PAF/PAFR interaction could clarify corresponding mechanisms involved in diabetic complications. Sahar Ghavidel Darestani, Mihoko Kurano, Atsushi Shinnakasu, Kiyoaki Yamamoto, Yukari Dochi, Kayo Uemura, Yuko Ikeda, Aiko Arimura, Hiroshi Arimura, Akira Kikuchi, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio Association between changes in the mRNA expression of platelet activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy Diabetology International, 11, 11–18(2020) This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: https://doi.org/10.1007/s13340-019-00394-w |
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| 言語 | en | |||||
| 収録雑誌名 |
en : Diabetology International 巻 11, p. 11-18, 発行日 2020 |
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| 作成日 | ||||||
| 日付 | 2020-01-14 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 言語 | ja-Kana | |||||
| 備考 | ||||||
| 値 | 【指導教員:西尾善彦】 | |||||
| date.appl | ||||||
| 値 | 【学位申請日】2019-07-03 | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-01-28 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第534号 | |||||
