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MHC確立クラウン系ミニブタ肝臓温虚血再灌流障害に対する一酸化炭素の保護効果
http://hdl.handle.net/10232/00030891
http://hdl.handle.net/10232/000308919f2a7674-5e61-4f89-98ca-61942cf65fcf
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Diss_室川_剛廣_ISK535_2019 (1.2 MB)
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Abstract_室川_剛廣_4515810170_2019 (169.2 kB)
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Result_Murokawa_Takahiro_isk_535 (522.0 kB)
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Comments_Murokawa_Takahiro_isk_535 (245.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-13 | |||||
| タイトル | ||||||
| タイトル | The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia-Reperfusion Injury in MHC-lnbred Miniature Swine | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | MHC確立クラウン系ミニブタ肝臓温虚血再灌流障害に対する一酸化炭素の保護効果 | |||||
| タイトル言語 | ja | |||||
| 著者 |
室川, 剛廣
× 室川, 剛廣 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Carbon monoxide | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Ischemia-reperfusion injury | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Liver | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Large animal model | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Proinflammatory cytokines | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | HMGB1 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: The development of treatment strategies to protect against ischemia-reperfusion injury (IRI) to livers is important not only for liver surgeries but also in regard to increasing the utilization of livers from marginal donors. In this study, we examined whether inhalational carbon monoxide (CO) therapy reduced IRI after a 45-minute (min) warm ischemia (WI) in a miniature swine model. Materials and methods: Six CLAWN miniature swine underwent a 45-min hepatic WI induced by clamping the portal vein and proper hepatic artery. Three animals were subjected to control conditions while the remaining three were treated with CO inhalation for a total of 345-min, including 120-min after reperfusion to maintain a concentration of CO-Hb under 15% (CO-treated group). IRI of the livers was evaluated by liver function tests, serum pro-inflammatory cytokines and liver biopsies. Results: All controls had statistically significant increased levels of liver enzymes compared to the CO-treated group (p<0.05). In controls, liver biopsies at 2 hours after reperfusion showed marked histological changes including diffuse hemorrhage, congestion, necrosis, vacuolization and neutrophil infiltration with apoptosis. In contrast, the CO-treated group showed less obvious or only minimal histological changes. Furthermore, increases in HMGB1, TNF-α and IL-6 in sera that were induced by IRI in controls were markedly inhibited by the CO-treatment. Conclusion: We demonstrated that low-dose CO inhalation reduces hepatic warm IRI, potentially through downregulation of pro-inflammatory mediators and activation of anti-apoptotic pathways. To our knowledge, this is the first report demonstrating CO-inhalation attenuated hepatic IRI following WI in a large animal model. Takahiro Murokawa, Hisashi Sahara, Mitsuhiro Sekijima, Thomas Pomposelli, Takehiro Iwanaga, Yurika Ichinari, Akira Shimizu & Kazuhiko Yamada The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia–Reperfusion Injury in MHC-Inbred Miniature Swine Journal of Gastrointestinal Surgery 24, 974–982 (2020) https://doi.org/10.1007/s11605-019-04283-0 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2020-01-14 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | springer | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 出版者言語 | ja-Kana | |||||
| 備考 | ||||||
| 備考 | 【指導教員:佐藤正宏】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2019-10-02 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-01-28 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第535号 | |||||
