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アイテム
非アルコール性脂肪性肝疾患は皮下および内臓肥満と関連する : 横断研究
http://hdl.handle.net/10232/00031132
http://hdl.handle.net/10232/0003113295550f66-2784-4ce7-8eda-ae7b9518f52f
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Diss_呉_建_ISK560_2020 (231.8 kB)
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Abstract_呉_建_4508800244_2019 (123.3 kB)
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Result_Kure_Takeshi_isk_560 (896.3 kB)
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Comments_Kure_Takeshi_isk_560 (365.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-07-08 | |||||
| タイトル | ||||||
| タイトル | Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity : A cross-sectional study | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 非アルコール性脂肪性肝疾患は皮下および内臓肥満と関連する : 横断研究 | |||||
| 言語 | ja | |||||
| 著者 |
呉, 建
× 呉, 建 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | metabolic syndrome | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | nonalcoholic fatty liver disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | subcutaneous obesity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | visceral obesity | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約(Abstract) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nonalcoholic fatty liver disease (NAFLD) is recognized as a hepatic manifestation of metabolic syndrome because of the association with visceral obesity. However, the association between NAFLD and subcutaneous fat accumulation remains unclear. The study population included 3197 participants in regular health checkups, who were both hepatitis B virus surface antigen and hepatitisCvirus antibody-negative, andconsumed<20g of alcohol per day. Theyweredivided according to 4 quantiles of subcutaneous fat area (SFA) and visceral fat area (VFA) on computed tomography. Fatty liver was diagnosed using ultrasonography (FL-US). The prevalence of FL-US increased across the SFA categories, even after adjusting for the VFA, in both men (P<.001) and women (P<.001). This significant association between FL-US and the SFA was already detected from the second SFA quantile. It is noteworthy that the mean body mass index (BMI) of the subjects in the second quantile was 23.7kg/m2 in men and 22.6kg/m2 in women. Independent positive associations were observed between alanine aminotransferase elevation, and both the SFA and VFA in men, while gamma glutamyl transpeptidase elevation was independently associated with the VFA, but not the SFA, in both men and women. Similarly, the components of metabolic syndrome were independently associated with the VFA, but were less strongly associated (or not associated at all) with the SFA. This cross-sectional study suggests that NAFLD is independently associated with both visceral and subcutaneous adiposity ab initio, which is a characteristic that distinguishes NAFLD from other components of metabolic syndrome. Takeshi Kure, Seiichi Mawatari, Yasushi Imamura, Kotaro Kumagai,Yasunari Hiramine, Hironori Miyahara, Shuji Kanmura, Akihiro Moriuchi, Hirofumi Uto, Masahisa Horiuchi Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity Medicine, 2019 98(46) p.e17879 http://dx.doi.org/10.1097/MD.0000000000017879 |
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| 言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2020-04-02 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Wolters Kluwer Health | |||||
| 言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 言語 | ja-Kana | |||||
| 備考 | ||||||
| 値 | 【指導教員:井戸章雄】 | |||||
| date.appl | ||||||
| 値 | 【学位申請日】2020-01-08 | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-04-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第560号 | |||||
