WEKO3
アイテム
オウバクの Streptococcus mutans に対する抗菌効果
http://hdl.handle.net/10232/00031362
http://hdl.handle.net/10232/000313625aa55891-b4b4-4222-9c8b-30db1230242d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Diss_辻井_利弥_ISK569_2020 (496.6 kB)
|
|
|
|
Abstract_辻井_利弥_4516800089_2020 (30.2 kB)
|
|
|
|
Result_Tsujii_Toshiya_isk_569 (169.8 kB)
|
|
|
|
Comments_Tsujii_Toshiya_isk_569 (88.1 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-01 | |||||
| タイトル | ||||||
| タイトル | Antibacterial activity of phellodendron bark against Streptococcus mutans | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | オウバクの Streptococcus mutans に対する抗菌効果 | |||||
| タイトル言語 | ja | |||||
| 著者 |
辻井, 利弥
× 辻井, 利弥 |
|||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | antibacterial agents and chemotherapy | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | bacteriology | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | pathogenesis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Streptococcus mutans | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Streptococcus mutans is a major cause of tooth decay due to its promotion of biofilm formation and acid production. Several plant extracts have been reported to have multiple biological activities such as anti‐inflammation and antibacterial effects. This study investigated the antibacterial activity of three plant extracts, phellodendron bark (PB), yucca, and black ginger, and found that PB had a stronger effect than the other extracts. Then, the minimum inhibitory concentration (MIC) of PB against 100 S. mutans strains was investigated. The MIC range of PB was 9.8–312.5 µg/mL. PB suppressed the growth kinetics of S. mutans in a dose‐dependent manner, even at sub‐MICs of PB. Then, we investigated the effect of PB on S. mutans virulence. The PB suppressed biofilm formation at high concentrations, although PB did not affect the expression of glucosyltransferase genes. Additionally, PB suppressed the decrease in pH from adding an excess of glucose. The expression of genes responsible for acid production was increased by the addition of excess glucose without PB, whereas their expression levels were not increased in the presence of 1× and 2× MIC of PB. Although PB showed a bacteriostatic effect on planktonic S. mutans cells, it was found that more than 2× MIC of PB showed a partial bactericidal effect on biofilm cells. In conclusion, PB not only showed antibacterial activity against S. mutans but also decreased the cariogenic activity in S. mutans. Toshiya Tsujii, Miki Kawada‐Matsuo, Hirono Migita, Kouji Ohta, Yuichi Oogai, Youichi Yamasaki, Hitoshi Komatsuzawa Antibacterial activity of phellodendron bark against Streptococcus mutans Microbiology and Immunology 64(6) p.424-434 2020 https://doi.org/10.1111/1348-0421.12787 |
|||||
| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2020-08-06 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | The Societies and John Wiley & Sons | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:山﨑要一】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2020-06-03 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(歯学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Dental Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-08-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第569号 | |||||
