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The aim of this study is to determine how shear stress affects platelets and coagulation factors.\nMETHODS:\nWe retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital.\nRESULTS:\nPlatelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG \u003e 100 mmHg) and lower (LPPG \u003c 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen.\nCONCLUSION:\nShear stress affects PLT count, PDW, and fibrinogen in patients with AS.", "subitem_description_type": "Other"}, {"subitem_description": "Kanda Hideaki, Yamakuchi Munekazu, Matsumoto Kazuhisa, Mukaihara Kosuke, Shigehisa Yoshiya, Tachioka Shuji, Okawa Masashi, Takenouchi Kazunori, Oyama Yoko, Hashiguchi Teruto, Imoto Yutaka\nDynamic changes in platelets caused by shear stress in aortic valve stenosis\nClinical Hemorheology and Microcirculation, 77(1), pp. 71-81, 2021\nThe final publication is available at IOS Press through https://doi.org/10.3233/CH-200928", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_55": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲総研第595号"}]}, "item_5_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "139399", "nameIdentifierScheme": 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Dynamic changes in platelets caused by shear stress in aortic valve stenosis
http://hdl.handle.net/10232/00031728
http://hdl.handle.net/10232/000317280b75864b-3dc3-4725-8460-26163913f17e
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2021-04-14 | |||||
タイトル | ||||||
タイトル | Dynamic changes in platelets caused by shear stress in aortic valve stenosis | |||||
別言語のタイトル | ||||||
その他のタイトル | 大動脈弁狭窄症におけるシアストレスによる血小板の動態 | |||||
著者 |
上田, 英昭
× 上田, 英昭 |
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著者よみ | ||||||
姓名 | カンダ, ヒデアキ | |||||
別言語の著者 | ||||||
姓名 | KANDA, Hideaki | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Aortic valve stenosis | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | platelet | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | plateletcrit | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | shear stress | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | pressure gradient | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | BACKGROUND AND OBJECTIVE: Turbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors. METHODS: We retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital. RESULTS: Platelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG > 100 mmHg) and lower (LPPG < 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen. CONCLUSION: Shear stress affects PLT count, PDW, and fibrinogen in patients with AS. |
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要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Kanda Hideaki, Yamakuchi Munekazu, Matsumoto Kazuhisa, Mukaihara Kosuke, Shigehisa Yoshiya, Tachioka Shuji, Okawa Masashi, Takenouchi Kazunori, Oyama Yoko, Hashiguchi Teruto, Imoto Yutaka Dynamic changes in platelets caused by shear stress in aortic valve stenosis Clinical Hemorheology and Microcirculation, 77(1), pp. 71-81, 2021 The final publication is available at IOS Press through https://doi.org/10.3233/CH-200928 |
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作成日 | ||||||
日付 | 2021-03-10 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 最終試験結果の要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文審査の要旨 | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者・出版者 | ||||||
出版者 | IOS Press | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
備考 | ||||||
備考 | 【指導教員:井本浩】 | |||||
date.appl | ||||||
【学位申請日】2021-02-03 | ||||||
学位名 | ||||||
学位名 | 博士(医学)Doctor of Philosophy in Medical Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2021-03-25 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第595号 |