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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Dynamic changes in platelets caused by shear stress in aortic valve stenosis

http://hdl.handle.net/10232/00031728
http://hdl.handle.net/10232/00031728
0b75864b-3dc3-4725-8460-26163913f17e
名前 / ファイル ライセンス アクション
Diss_上田_英昭_ISK595_2020.pdf Diss_上田_英昭_ISK595_2020 (817.6 kB)
Abstract_上田_英昭_4517810123_2020.pdf Abstract_上田_英昭_4517810123_2020 (24.2 kB)
Result_Kanda_Hideaki_isk_595.pdf Result_Kanda_Hideaki_isk_595 (173.3 kB)
Comments_Kanda_Hideaki_isk_595.pdf Comments_Kanda_Hideaki_isk_595 (91.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2021-04-14
タイトル
タイトル Dynamic changes in platelets caused by shear stress in aortic valve stenosis
別言語のタイトル
その他のタイトル 大動脈弁狭窄症におけるシアストレスによる血小板の動態
著者 上田, 英昭

× 上田, 英昭

WEKO 139398

上田, 英昭

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著者よみ
姓名 カンダ, ヒデアキ
別言語の著者
姓名 KANDA, Hideaki
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 Aortic valve stenosis
キーワード
主題言語 en
主題Scheme Other
主題 platelet
キーワード
主題言語 en
主題Scheme Other
主題 plateletcrit
キーワード
主題言語 en
主題Scheme Other
主題 shear stress
キーワード
主題言語 en
主題Scheme Other
主題 pressure gradient
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 BACKGROUND AND OBJECTIVE:
Turbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors.
METHODS:
We retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital.
RESULTS:
Platelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG > 100 mmHg) and lower (LPPG < 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen.
CONCLUSION:
Shear stress affects PLT count, PDW, and fibrinogen in patients with AS.
要約(Abstract)
内容記述タイプ Other
内容記述 Kanda Hideaki, Yamakuchi Munekazu, Matsumoto Kazuhisa, Mukaihara Kosuke, Shigehisa Yoshiya, Tachioka Shuji, Okawa Masashi, Takenouchi Kazunori, Oyama Yoko, Hashiguchi Teruto, Imoto Yutaka
Dynamic changes in platelets caused by shear stress in aortic valve stenosis
Clinical Hemorheology and Microcirculation, 77(1), pp. 71-81, 2021
The final publication is available at IOS Press through https://doi.org/10.3233/CH-200928
作成日
日付 2021-03-10
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 鹿児島大学
公開者・出版者
出版者 IOS Press
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:井本浩】
date.appl
【学位申請日】2021-02-03
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2021-03-25
学位授与番号
学位授与番号 甲総研第595号
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