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Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
http://hdl.handle.net/10232/00031967
http://hdl.handle.net/10232/000319672dc82746-1060-448d-8358-13a91d160a3b
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2022-05-23 | |||||
タイトル | ||||||
タイトル | Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice | |||||
別言語のタイトル | ||||||
その他のタイトル | マウスにおけるリナロール香気誘発性鎮痛にはオレキシン性下行性疼痛抑制系が関与している | |||||
著者 |
比嘉, 憂理奈
× 比嘉, 憂理奈 |
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著者よみ | ||||||
姓名 | ヒガ, ユリナ | |||||
別言語の著者 | ||||||
姓名 | HIGA, Yurina | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuronal circuit mechanisms underlying this effect have not been fully addressed. In this study, we focused on the descending orexinergic projection to the spinal cord and examined whether this pathway contributes to the effect. We assessed the effect of intrathecal administration of orexin receptor antagonists on linalool odor-induced analgesia in the tail capsaicin test. We found that the selective orexin type 1 receptor antagonist, but not the selective orexin type 2 receptor antagonist, prevented the odor-induced analgesic effect. Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist. These results indicate that linalool odor exposure drives the orexinergic descending pathway and suppresses nociceptive information flow at the spinal level. Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice Scientific Reports 11, 9224, 2021 https://doi.org/10.1038/s41598-021-88359-5 |
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作成日 | ||||||
日付 | 2022-01-11 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 最終試験結果の要旨 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文審査の要旨 | |||||
公開者・出版者 | ||||||
出版者 | nature | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
備考 | ||||||
備考 | 【指導教員:杉村光隆】 | |||||
date.appl | ||||||
【学位申請日】2021-11-04 | ||||||
学位名 | ||||||
学位名 | 博士(歯学)Doctor of Philosophy in Dental Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2022-01-18 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第629号 |