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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice

http://hdl.handle.net/10232/00031967
http://hdl.handle.net/10232/00031967
2dc82746-1060-448d-8358-13a91d160a3b
名前 / ファイル ライセンス アクション
Diss_比嘉_憂理奈_ISK629_2021.pdf Diss_比嘉_憂理奈_ISK629_2021 (3.0 MB)
license.icon
Abstract_比嘉_憂理奈_4517810295_2021.pdf Abstract_比嘉_憂理奈_4517810295_2021 (128.1 kB)
Result_Higa_Yurina_isk_629.pdf Result_Higa_Yurina_isk_629 (6.0 MB)
Comments_Higa_Yurina_isk_629.pdf Comments_Higa_Yurina_isk_629 (2.4 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-05-23
タイトル
タイトル Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
別言語のタイトル
その他のタイトル マウスにおけるリナロール香気誘発性鎮痛にはオレキシン性下行性疼痛抑制系が関与している
著者 比嘉, 憂理奈

× 比嘉, 憂理奈

WEKO 140614

比嘉, 憂理奈

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著者よみ
姓名 ヒガ, ユリナ
別言語の著者
姓名 HIGA, Yurina
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuronal circuit mechanisms underlying this effect have not been fully addressed. In this study, we focused on the descending orexinergic projection to the spinal cord and examined whether this pathway contributes to the effect. We assessed the effect of intrathecal administration of orexin receptor antagonists on linalool odor-induced analgesia in the tail capsaicin test. We found that the selective orexin type 1 receptor antagonist, but not the selective orexin type 2 receptor antagonist, prevented the odor-induced analgesic effect. Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist. These results indicate that linalool odor exposure drives the orexinergic descending pathway and suppresses nociceptive information flow at the spinal level.

Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki
Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice
Scientific Reports 11, 9224, 2021
https://doi.org/10.1038/s41598-021-88359-5
作成日
日付 2022-01-11
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 nature
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:杉村光隆】
date.appl
【学位申請日】2021-11-04
学位名
学位名 博士(歯学)Doctor of Philosophy in Dental Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2022-01-18
学位授与番号
学位授与番号 甲総研第629号
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