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炭粉沈着をきたした胸膜におけるリンパ管の構造的・機能的変化: リンパ節スキップ転移への影響
http://hdl.handle.net/10232/00032024
http://hdl.handle.net/10232/000320240b988094-a7a2-4693-8ff2-56d49d9678e5
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Diss_武田_亜矢_ISK663_2022 (3.0 MB)
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Abstract_武田_亜矢_4519810221_2022 (24.1 kB)
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Result_Takeda_Aya_isk_663 (120.9 kB)
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Comments_Takeda_Aya_isk_663 (56.8 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-06-21 | |||||
| タイトル | ||||||
| タイトル | Altered lymphatic structure and function in pleural anthracosis: Negative role in skip N2 metastasis | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 炭粉沈着をきたした胸膜におけるリンパ管の構造的・機能的変化: リンパ節スキップ転移への影響 | |||||
| タイトル言語 | ja | |||||
| 著者 |
武田, 亜矢
× 武田, 亜矢 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lung cancer | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Pleural lymphatics | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Indocyanine green fluorescence | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Anthracosis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Skip lymph node metastasis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | OBJECTIVES: The present study investigated whether or not pleural anthracosis is associated with changes in the pleural lymphatic structures or function, which would interfere with nodal skip metastasis. METHODS: This study comprised 2 different case series. In the first series, we observed pleural lymphatic drainage using near-infrared fluorescent endoscopy by the subpleural injection of indocyanine green immediately after thoracotomy for lung cancer. We also performed a histological assessment of the pleura. In the second series, we reviewed the nodal metastatic pattern (skip or non-skip metastasis) in pathological N2 lung cancer involving the pleura. These findings were compared with the severity of pleural anthracosis, which was quantified by thoracoscopic vision and a software-based imaging analysis. RESULTS: In the first series (n = 42), pleural lymphatic drainage was not visualized in 19 (45%) patients who had relatively severe anthracosis, while it was visualized in the remaining 23 (55%) patients who had relatively minimal anthracosis. Histologically, severe anthracosis was associated with pleural thickening accompanied by a decreased incidence of straight-running lymphatic vessels and, in turn, an increased incidence of short lymphatic vessels, which was suggested to be the result of pleural remodelling. In the second series (n = 53), a skip metastatic pattern was found in 24 (45%) patients who predominantly had less-severe anthracosis, while a non-skip metastatic pattern was found in 29 (55%) patients who predominantly had severe anthracosis. CONCLUSIONS: Pleural anthracosis was associated with pathological changes in the pleural lymphatics and decreased pleural lymphatic drainage, thereby interfering with nodal skip metastasis. This is a pre-copyedited, author-produced version of an article accepted for publication in [European Journal of Cardio-Thoracic Surgery] following peer review. The version of record [Aya Takeda, Kazuhiro Ueda, Masaya Aoki, Toshiyuki Nagata, Go Kamimura, Tadashi Umehara, Takuya Tokunaga, Kazuhiro Tabata, Akihide Tanimoto, Masami Sato, "Altered lymphatic structure and function in pleural anthracosis: negative role in skip N2 metastasis"; European Journal of Cardio-Thoracic Surgery 2022, 62(3), ezac123] is available online at: https://academic.oup.com/ejcts/article/62/3/ezac123/6535926 [https://doi.org/10.1093/ejcts/ezac123]. |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2022-06-03 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:佐藤雅美】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2022-04-06 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2022-06-13 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第663号 | |||||
