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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Detecting Early-Stage Oral Cancer from Clinically Diagnosed Oral Potentially Malignant Disorders by DNA Methylation Profile

http://hdl.handle.net/10232/00032140
http://hdl.handle.net/10232/00032140
0754dbd3-faca-404d-aeef-aff79eb71e19
名前 / ファイル ライセンス アクション
Diss_森_和樹_ISK674_2022.pdf Diss_森_和樹_ISK674_2022 (1.1 MB)
license.icon
Abstract_森_和樹_4518810389_2022.pdf Abstract_森_和樹_4518810389_2022 (159.9 kB)
Result_MORI_Kazuki_isk_674.pdf Result_MORI_Kazuki_isk_674 (99.3 kB)
Comments_MORI_Kazuki_isk_674.pdf Comments_MORI_Kazuki_isk_674 (56.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-10-27
タイトル
タイトル Detecting Early-Stage Oral Cancer from Clinically Diagnosed Oral Potentially Malignant Disorders by DNA Methylation Profile
別言語のタイトル
その他のタイトル 臨床的に口腔潜在的悪性疾患と診断された病変から、早期癌を検出するDNAメチル化を指標とした検査法
著者 森, 和樹

× 森, 和樹

WEKO 141341

森, 和樹

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著者よみ
姓名 モリ, カズキ
別言語の著者
姓名 MORI, Kazuki
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 oral cancer
キーワード
主題言語 en
主題Scheme Other
主題 oral squamous carcinoma
キーワード
主題言語 en
主題Scheme Other
主題 oral potentially malignant disorders
キーワード
主題言語 en
主題Scheme Other
主題 gargle fluid
キーワード
主題言語 en
主題Scheme Other
主題 DNA methylation
キーワード
主題言語 en
主題Scheme Other
主題 biomarker
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Clinically, early-stage oral cancers are difficult to distinguish from oral potentially malignant disorders (OPMDs), and invasive tissue biopsy should be performed to determine a treatment strategy. Previously, we focused on gargle fluid as a noninvasive testing method and reported aberrant methylation in gargle fluid in patients with oral cancer. This study aimed to distinguish early-stage oral cancer from clinically diagnosed OPMDs using gargle fluid samples. We collected gargle fluid samples from 40 patients who were clinically diagnosed with OPMDs in the training set; among them, 9 patients were pathologically diagnosed with oral cancer. Methylation levels of 25 tumor suppressor genes were analyzed using the methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) method. We found that a combination of six genes (TP73, CASP8, RARB, KLLN, GSTP1, and CHFR) could distinguish oral cancer from clinically diagnosed OPMDs with high diagnostic performance (area under the curve [AUC], 0.885; sensitivity, 77.8%; and specificity, 87.1%). Additionally, the panel comprised of the six methylated genes was validated in the test set. Furthermore, when compared with cytology testing, the panel could accurately detect oral cancer. The present methylated gene panel may serve as a novel biomarker for oral cancer.

Kazuki Mori, Tomofumi Hamada, Mahiro Beppu, Hiroki Tsuchihashi, Yuichi Goto, Kenichi Kume, Hiroshi Hijioka, Keitaro Nishi, Yumiko Mishima and Tsuyoshi Sugiura
Detecting Early-Stage Oral Cancer from Clinically Diagnosed Oral Potentially Malignant Disorders by DNA Methylation Profile
Cancers 2022, 14(11), 2646
https://doi.org/10.3390/cancers14112646
作成日
日付 2022-10-07
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 MDPI
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:杉浦剛】
date.appl
【学位申請日】2022-08-03
学位名
学位名 博士(歯学)Doctor of Philosophy in Dental Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2022-10-18
学位授与番号
学位授与番号 甲総研第674号
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