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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice

http://hdl.handle.net/10232/00032412
http://hdl.handle.net/10232/00032412
9a870523-e26a-48fa-a5a5-26e6b7ddabf0
名前 / ファイル ライセンス アクション
Diss_政所_祐太郎_ISK684_2022.pdf Diss_政所_祐太郎_ISK684_2022 (2.1 MB)
license.icon
Abstract_政所_祐太郎_4517810348_2022.pdf Abstract_政所_祐太郎_4517810348_2022 (132.3 kB)
Result_MADOKORO_Yutaro_isk_684.pdf Result_MADOKORO_Yutaro_isk_684 (166.9 kB)
Comments_MADOKORO_Yutaro_isk_684.pdf Comments_MADOKORO_Yutaro_isk_684 (57.0 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2023-03-14
タイトル
タイトル Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice
別言語のタイトル
その他のタイトル 敗血症マウスにおける早期アスコルビン酸投与による血管内皮細胞障害の抑制
著者 政所, 祐太郎

× 政所, 祐太郎

WEKO 142149

政所, 祐太郎

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著者よみ
姓名 マドコロ, ユウタロウ
別言語の著者
姓名 MADOKORO, Yutaro
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 ascorbic acid
キーワード
主題言語 en
主題Scheme Other
主題 sepsis
キーワード
主題言語 en
主題Scheme Other
主題 tetrahydrobiopterin
キーワード
主題言語 en
主題Scheme Other
主題 endothelial dysfunction
キーワード
主題言語 en
主題Scheme Other
主題 syndecan
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Oxidation of BH4, a cofactor of nitric oxide synthase (NOS), produces reactive oxygen species (ROS) through uncoupling of NOS and affects vascular endothelial dysfunction. Ascorbic acid (AsA) inhibits the oxidation of BH4 and reduces ROS. However, the kinetic changes of BH4 in sepsis and its effect on the kinetic changes in AsA administration therapy, as well as the appropriate timing of AsA administration for AsA therapy to be effective, are unclear. Mice with sepsis, induced by cecal ligation and puncture (CLP), were examined for the effect of AsA administration (200 mg/kg) on vascular endothelial cell dysfunction at two administration timings: early group (AsA administered immediately after CLP) and late group (AsA administered 12 h after CLP). Survival rates were compared between the early and late administration groups, and vascular endothelial cell damage, indicated by the dihydrobiopterin/tetrahydrobiopterin ratio, serum syndecan-1, and endothelial nitric oxide synthase, as well as liver damage, were examined. The early group showed significantly improved survival compared to the non-treatment group (p < 0.05), while the late group showed no improved survival compared to the non-treatment group. Compared to the non-treated group, the early AsA group showed less oxidation of BH4 in sepsis. Syndecan1, a marker of vascular endothelial cell damage, was less elevated and organ damage was reduced in the early AsA-treated group. In septic mice, early AsA administration immediately after CLP may protect vascular endothelial cells by inhibiting BH4 oxidation, thereby reducing organ dysfunction and improving survival.

Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose and Yasuyuki Kakihana
Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice
Frontiers in Pharmacology 13:929448
https://doi.org/10.3389/fphar.2022.929448
作成日
日付 2023-03-03
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 Frontiers
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:垣花泰之】
date.appl
【学位申請日】2022-12-07
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2023-03-10
学位授与番号
学位授与番号 甲総研第684号
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