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  1. 医歯学総合研究科
  2. 医歯学総合研究科・博士論文

Insufficient blood pressure control is independently associated with increased arterial stiffness

http://hdl.handle.net/10232/00032421
http://hdl.handle.net/10232/00032421
1ae5659f-68ee-4e0c-8f66-69951384e17f
名前 / ファイル ライセンス アクション
Diss_川畑_孟子_ISK693_2022.pdf Diss_川畑_孟子_ISK693_2022 (457.4 kB)
Abstract_川畑_孟子_4519810169_2022.pdf Abstract_川畑_孟子_4519810169_2022 (83.0 kB)
Result_KAWABATA_takeko_isk_693.pdf Result_KAWABATA_takeko_isk_693 (113.6 kB)
Comments_KAWABATA_takeko_isk_693.pdf Comments_KAWABATA_takeko_isk_693 (56.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2023-03-14
タイトル
タイトル Insufficient blood pressure control is independently associated with increased arterial stiffness
別言語のタイトル
その他のタイトル 不十分な血圧コントロールは独立して動脈硬化度の進行と関連する
著者 川畑, 孟子

× 川畑, 孟子

WEKO 142176

川畑, 孟子

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著者よみ
姓名 カワバタ, タケコ
別言語の著者
姓名 KAWABATA, Takeko
言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 Antihypertensive agents
キーワード
主題言語 en
主題Scheme Other
主題 Blood pressure
キーワード
主題言語 en
主題Scheme Other
主題 Risk factors
キーワード
主題言語 en
主題Scheme Other
主題 Vascular stiffness
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
要約(Abstract)
内容記述タイプ Other
内容記述 Hypertension is a risk factor for atherosclerosis. Achieving the therapeutic target value of blood pressure (BP) prevents the onset of cardiovascular events; however, it is not clear how antihypertensive drug use and BP control status relate to arterial stiffness. The purpose of this study is to investigate the relationship between BP control status with or without antihypertensive drugs and arterial stiffness. Nine hundred eighty individuals (mean age: 68 ± 11 years) who participated in a community-based cohort study were enrolled. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). Higher BP was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. Participants were divided into four groups: normal, non higher BP without antihypertensive drugs (n = 421); untreated, higher BP without antihypertensive drugs (n = 174); good control, non higher BP with antihypertensive drugs (n = 209); and poor control, higher BP with antihypertensive drugs (n = 176). In multivariable logistic analysis adjusted for age, sex, dyslipidemia and diabetes mellitus medication use, obesity, smoking, alcohol drinking, and heart rate at the CAVI measurement for a high CAVI—using a borderline cutoff value of 8.0—the other three groups were significantly associated with a high CAVI when compared with the normal group. By contrast, multivariable logistic analysis of a high CAVI using an abnormal cutoff value of 9.0 demonstrated that the poor control and untreated groups were significantly associated with a high CAVI, whereas the good control group was not. In conclusion, even with antihypertensive drugs, poor BP control is independently associated with a high CAVI.

Takeko Kawabata, Takuro Kubozono, Satoko Ojima, Shin Kawasoe, Yuichi Akasaki, Anwar Ahmed Salim, Yoshiyuki Ikeda, Masaaki Miyata, Toshihiro Takenaka & Mitsuru Ohishi
Insufficient blood pressure control is independently associated with increased arterial stiffness
Hypertension Research 45, 1861–1868 (2022)
https://doi.org/10.1038/s41440-022-01039-3
作成日
日付 2023-03-03
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文全文
ファイル(説明)
内容記述タイプ Other
内容記述 博士論文要旨
ファイル(説明)
内容記述タイプ Other
内容記述 最終試験結果の要旨
ファイル(説明)
内容記述タイプ Other
内容記述 論文審査の要旨
公開者・出版者
出版者 Springer Nature
公開者・出版者
出版者 鹿児島大学
公開者よみ
公開者よみ カゴシマ ダイガク
公開者別名
公開者別名 Kagoshima University
備考
備考 【指導教員:大石充】
date.appl
【学位申請日】2022-10-05
学位名
学位名 博士(医学)Doctor of Philosophy in Medical Science
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17701
学位授与機関名 鹿児島大学
学位授与年月日
学位授与年月日 2023-03-23
学位授与番号
学位授与番号 甲総研第693号
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