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Clinical significance of ALKBH4 expression in non-small cell lung cancer
http://hdl.handle.net/10232/00032542
http://hdl.handle.net/10232/00032542a52539de-03c6-46fd-b135-9ca16bc42917
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2218676X_v11(7)_p2040-2049 (687.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-05-11 | |||||
| タイトル | ||||||
| タイトル | Clinical significance of ALKBH4 expression in non-small cell lung cancer | |||||
| タイトル言語 | en | |||||
| 著者 |
Aoki, Masaya
× Aoki, Masaya× Ueda, Kazuhiro× Kamimura, Go× Iwamoto, Yoshiyuki× Ikehata, Mizuki× Tabata, Keisuke× Sakagami, Yuri× Morizono, Shoichiro× Tokunaga, Takuya× Umehara, Tadashi× Harada－Takeda, Aya× Maeda, Koki× Nagata, Toshiyuki× Kariatsumari, Kota× Furukawa, Tatsuhiko× Tsujikawa, Kazutake× Sato, Masami |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ALKBH4 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | non-small cell lung cancer (NSCLC) | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | complete resection | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | carcinogenesis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prognosis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Gene methylation is deeply involved in epigenetics and affects both the development and maintenance of homeostasis and carcinogenesis. ALKBH4 is a member of the AlkB homolog (ALKBH) family that controls demethylation of DNA and RNA. Methods: This study enrolled 160 patients with non-small cell lung cancer (NSCLC) who underwent complete resection. The expression of ALKBH4 in cancer tissue was evaluated by immunohistochemistry. The correlation among the expression of ALKBH4, clinicopathological factors, and prognostic outcome was evaluated. Results: In the NSCLC clinical samples, the expression of ALKBH4 was identified not only in cell membranes but also in the cytoplasm of cancer cells. In 140 of 160 cases, ALKBH4 was more highly expressed in the cancerous tissue than in the surrounding normal tissue. The proportion of cancer cells expressing ALKBH4 was higher in adenocarcinoma than in other histological types. In addition, the expression intensity of ALKBH4 in each cancer cell was also stronger in adenocarcinoma than in squamous cell carcinoma. The expression of ALKBH4 was not associated with clinicopathological factors, except for histological type. In adenocarcinoma, the recurrence-free survival (RFS) and overall survival (OS) rates were significantly lower in the ALKBH4-positive group than in the ALKBH4-negative group (P=0.008, 0.031, respectively). A multivariate logistic regression analysis indicated that the ALKBH4 expression was an independent prognostic factor for RFS (P=0.003) and OS (P=0.013). The expression of ALKBH4 was observed in all four patients with adenocarcinoma in situ. Conclusions: The ALKBH4 expression may be a useful predictor of the postoperative outcomes of lung adenocarcinoma (LUAD) patients. Masaya Aoki, Kazuhiro Ueda, Go Kamimura, Yoshiyuki Iwamoto, Mizuki Ikehata, Keisuke Tabata, Yuri Sakagami, Shoichiro Morizono, Takuya Tokunaga, Tadashi Umehara, Aya Harada-Takeda, Koki Maeda, Toshiyuki Nagata, Kota Kariatsumari, Tatsuhiko Furukawa, Kazutake Tsujikawa, Masami Sato Clinical significance of ALKBH4 expression in non-small cell lung cancer Translational Cancer Research 2022;11(7):2040-2049 https://dx.doi.org/10.21037/tcr-22-39 |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Translational Cancer Research 巻 11, 号 7, p. 2040-2049, 発行日 2022-07-30 |
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| 作成日 | ||||||
| 日付 | 2022-07-30 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 2218676X | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| 公開者・出版者 | ||||||
| 出版者 | AME Publishing Company | |||||
| 出版者言語 | en | |||||
