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Different Cytokine Production in Tax-Expressing Cells between Patients with Human T Cell Lymphotropic Virus Type I (HTLV-I)–Associated Myelopathy/Tropical Spastic Paraparesis and Asymptomatic HTLV-I Carriers
http://hdl.handle.net/10232/0002000342
http://hdl.handle.net/10232/0002000342126f2926-02c2-4219-8d63-b11bb5271698
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-05-24 | |||||
| タイトル | ||||||
| タイトル | Different Cytokine Production in Tax-Expressing Cells between Patients with Human T Cell Lymphotropic Virus Type I (HTLV-I)–Associated Myelopathy/Tropical Spastic Paraparesis and Asymptomatic HTLV-I Carriers | |||||
| タイトル言語 | en | |||||
| 著者 |
古川, 良尚
× 古川, 良尚× Saito, Mineki× Matsumoto, Wataru× Usuku, Koichiro× Tanaka, Yuetsu× Izumo, Shuji× Osame, Mitsuhiro |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Human T cell lymphotropic virus type I (HTLV-I) provirus load has been reported to be generally higher in patients with HTLV-I–associated myelopathy/tropical spastic paraparesis (HAM/TSP) than in asymptomatic HTLV-I carriers (ACs). However, some ACs have a high HTLV-I provirus load comparable with that in patients with HAM/TSP. To examine whether other factors influence the outcome of HTLV-I infection in patients with HAM/TSP and ACs, we analyzed spontaneous Tax expression and cytokine production in peripheral blood mononuclear cells using flow cytometry. The Tax expression in HTLV-I–infected cells (percentage of Tax expressing cells/HTLV-I provirus load when assumed 1 copy/cell) and the intensity of Tax expression did not differ between these 2 groups. However, the production of interferon-γ and tumor necrosis factor–α in Tax-expressing cells was significantly lower in ACs with high HTLV-I provirus load than in patients with HAM/TSP. This result suggests that the production of inflammatory cytokines in Tax-expressing cells is one of the factors that contribute to the development of HAM/TSP | |||||
| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This is a pre-copyedited, author-produced version of an article accepted for publication in [ Journal of Infectious Diseases ] following peer review. The version of record [ Yoshitaka Furukawa, Mineki Saito, Wataru Matsumoto, Koichiro Usuku, Yuetsu Tanaka, Shuji Izumo, Mitsuhiro Osame Different Cytokine Production in Tax-Expressing Cells between Patients with Human T Cell Lymphotropic Virus Type I (HTLV-I)–Associated Myelopathy/Tropical Spastic Paraparesis and Asymptomatic HTLV-I Carriers The Journal of Infectious Diseases, Volume 187, Issue 7, 1 April 2003, Pages 1116–1125 ] is available online at: https://doi.org/10.1086/368379 https://academic.oup.com/jid/article/187/7/1116/800443?login=true |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Journal of Infectious Diseases 巻 187, 号 7, p. 1116-1125, 発行日 2003-04-01 |
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| 作成日 | ||||||
| 日付 | 2003-04-01 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 00221899 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA0070010X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1086/368379 | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 公開者・出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 出版者言語 | en | |||||
