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Human T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo
http://hdl.handle.net/10232/0002000343
http://hdl.handle.net/10232/0002000343bfab336f-6856-4e52-8e53-3ad8fb668725
| 名前 / ファイル | ライセンス | アクション |
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P12_aids_hr (Revised） (295 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2024-05-24 | |||||
| タイトル | ||||||
| タイトル | Human T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo | |||||
| タイトル言語 | en | |||||
| 著者 |
古川, 良尚
× 古川, 良尚× Usuku, Koichiro× Izumo, Shuji× Osame, Mitsuhiro |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The function of the p12I protein of human T cell lymphotropic virus type I (HTLV-I) has been under debate. p12K (lysine) and p12R (arginine) variants of this protein at amino acid 88 and a shorter life of p12K had been reported by another group. Because HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients usually have a higher provirus load than asymptomatic HTLV-I carriers (ACs), and p12I had been suggested to confer a proliferative effect on HTLV-I-infected cells in vitro, it is possible that the relatively unstable p12K is less frequent in HAM/TSP patients than in ACs. To elucidate whether p12K and other alterations in the p12 gene were related to the outcome of HTLV-I infection, we sequenced the p12 gene in 144 HAM/TSP patients, 41 adult T cell leukemia (ATL) patients, and in 46 ACs. p12K was observed in only two HAM/TSP patients, but was not present in either ATL patients or ACs. Interestingly, a premature termination codon in the p12 was observed in 5.6% of HAM/TSP patients and in 4.9% of ATL patients but none was found in ACs. The p12 initiation codon was destroyed in one HAM/TSP patient. These HTLV-I variants with truncated p12 protein or with a destroyed initiation codon in the p12 gene appeared to have been transmitted in the subjects’ families. These findings suggest that p12 is dispensable for the transmission and maintenance of HTLV-I infection, although it is premature to conclude that sequence varitation in the p12 gene is associated with differences in the outcome of HTLV-I infection. | |||||
| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This is the accepted version of the following article: [ Yoshitaka Furukawa, Koichiro Usuku, Shuji Izumo, and Mitsuhiro Osame Human T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo AIDS Research and Human Retroviruses 2004 20:10, 1092-1099 ], which has now been formally published in final form at [ AIDS Research and Human Retroviruses ] at [ https://doi.org/10.1089/aid.2004.20.1092 ]. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions. |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : AIDS Research and Human Retroviruses 巻 20, 号 10, p. 1092-1099, 発行日 2004-10-18 |
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| 作成日 | ||||||
| 日付 | 2004-10-18 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 08892229 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA10689080 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1089/aid.2004.20.1092 | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 公開者・出版者 | ||||||
| 出版者 | Mary Ann Liebert | |||||
| 出版者言語 | en | |||||
