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HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia
http://hdl.handle.net/10232/0002000344
http://hdl.handle.net/10232/0002000344f497222b-e704-4606-a9f2-7c2cb805039f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IJC-04-2515(Furukawa accepted) (225 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2024-05-24 | |||||
| タイトル | ||||||
| タイトル | HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia | |||||
| タイトル言語 | en | |||||
| 著者 |
古川, 良尚
× 古川, 良尚× TARA, Mitsutoshi× Izumo, Shuji× Arimura, Kimiyoshi× Osame, Mitsuhiro |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | viral escape | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | INK4 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | p53 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ATL | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In the pathogenesis of adult T cell leukemia (ATL), an oncogenetic role of the human T cell lymphotropic virus type I (HTLV-I) Tax protein, viral escape from the host immune system, and host genetic changes have been proposed as contributory factors. We examined the premature stop codons in tax gene as one of the mutations that may lead to escape of HTLV-I from the cytotoxic T lymphocyte (CTL) response in HTLV-I carriers, to test whether a putative CTL escape mutant can emerge in the early stage of ATL development and whether HTLV-I infected cells with such a mutation can proliferate subsequently. We also examined deletion of cyclin-dependent kinase inhibitor 4 (INK4) genes and mutation of p53 gene in combination with changes in the HTLV-I genome in acute type ATL to test whether host genetic changes promoted the malignant transformation of ATL cells that carry putative CTL escape mutations. The premature stop codon in tax gene existed in many non-ATL HTLV-I carriers as a minor population but not in the commonest HTLV-I sequence of the individual. This minor population with a premature stop codon did not expand subsequently in 3 asymptomatic carriers tested. There were cases who had a mutation or deletion in HTLV-I who also have either deletion of INK4 genes or mutation in p53 gene. Our findings suggest that CTL escape mutation can occur at an early stage of ATL development, and that certain host genetic changes favor the development of the aggressive form of ATL. | |||||
| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Yoshitaka Furukawa, Mitsutoshi Tara, Shuji Izumo, Kimiyoshi Arimura, Mitsuhiro Osame HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia Int. J. Cancer: 118, 381–387 (2006) https://doi.org/10.1002/ijc.21328 |
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| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This is the peer reviewed version of the following article: [ https://onlinelibrary.wiley.com/doi/10.1002/ijc.21328 ], which has been published in final form at [ https://doi.org/10.1002/ijc.21328 ]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : International Journal of Cancer 巻 118, p. 381-387, 発行日 2005-07-28 |
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| 作成日 | ||||||
| 日付 | 2005-07-28 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| ISSN | 10970215 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA11621537 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1002/ijc.21328 | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 公開者・出版者 | ||||||
| 出版者 | Wiley | |||||
| 出版者言語 | en | |||||
