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健康住民における洞調律心電図を用いたシンプルな心房細動発症予測リスクスコアの創出
http://hdl.handle.net/10232/0002000854
http://hdl.handle.net/10232/0002000854d0b058b7-a21d-44bb-bb1e-b0c292cf5c6f
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2025-05-07 | |||||
| タイトル | ||||||
| タイトル | Simple risk scoring using sinus rhythm electrocardiograms predicts the incidence of atrial fibrillation in the general population | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 健康住民における洞調律心電図を用いたシンプルな心房細動発症予測リスクスコアの創出 | |||||
| タイトル言語 | ja | |||||
| 著者 |
鎌田, 博之
× 鎌田, 博之 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Atrial fibrillation (AF) is an arrhythmic disease. Prediction of AF development in healthy individuals is important before serious complications occur. We aimed to develop a risk prediction score for future AF using participants’ data, including electrocardiogram (ECG) measurements and information such as age and sex. We included 88,907 Japanese participants, aged 30–69 years, who were randomly assigned to derivation and validation cohorts in a ratio of 1:1. We performed multivariate logistic regression analysis and obtained the standardised beta coefficient of relevant factors and assigned scores to them. We created a score based on prognostic factors for AF to predict its occurrence after five years and applied it to validation cohorts to assess its reproducibility. The risk score ranged from 0 to 17, consisting of age, sex, PR prolongation, QT corrected for heart rate prolongation, left ventricular hypertrophy, premature atrial contraction, and left axis deviation. The area under the curve was 0.75 for the derivation cohort and 0.73 for the validation cohort. The incidence of new-onset AF reached over 2% at 10 points of the risk score in both cohorts. Thus, in this study, we showed the possibility of predicting new-onset AF using ECG findings and simple information. | |||||
| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hiroyuki Kamada, Shin Kawasoe, Takuro Kubozono, Yuichi Ninomiya, Kei Enokizono, Issei Yoshimoto, Yasuhisa Iriki, Yoshiyuki Ikeda, Masaaki Miyata, Hironori Miyahara, Koichi Tokushige & Mitsuru Ohishi Simple risk scoring using sinus rhythm electrocardiograms predicts the incidence of atrial fibrillation in the general population Sci Rep 14, 9628 (2024) https://doi.org/10.1038/s41598-024-60219-y |
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| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The version of record of this article, first published in scientific reports, is available online at Publisher’s website: https://doi.org/10.1038/s41598-024-60219-y | |||||
| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2025-03-07 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Springer Nature | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:大石充】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2024-07-03 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2025-03-25 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第774号 | |||||
