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Upregulation of Notch pathway molecules in oral squamous cell carcinoma
http://hdl.handle.net/10232/19984
http://hdl.handle.net/10232/199845cf15285-b4cb-4d0d-982c-d769a61160c3
| 名前 / ファイル | ライセンス | アクション |
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Upregulation of Notch pathway molecules in oral squamous cell carcinoma.pdf (595.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-02-10 | |||||
| タイトル | ||||||
| タイトル | Upregulation of Notch pathway molecules in oral squamous cell carcinoma | |||||
| タイトル言語 | en | |||||
| 著者 |
比地岡, 浩志
× 比地岡, 浩志× 瀬戸口, 啓夫× 宮脇, 昭彦× Gao, Hui× 石田, 喬之× 小宮, 節郎× 中村, 典史 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | oral squamous cell carcinoma | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Notch | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | γ-secretase inhibitor | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The constitutive activation of the Notch pathway has been demonstrated in various types of malignancies. However, it remains unclear how the Notch pathway is involved in the pathogenesis of oral squamous cell carcinoma (OSCC). We investigated the expression of Notch pathway molecules in OSCC cell lines and biopsy specimens and examined the effect of Notch pathway inhibition. Reverse transcription-polymerase chain reaction revealed upregulation of Notch1, Notch2, Jagged1, HES1 and HEY1 in both OSCC cell lines and biopsy specimens. Immunohistochemical examination showed that the Notch intracellular domain accumulates in the nucleus of cells in OSCC cell lines and biopsy specimens. In addition, Jagged1 is expressed in the cytoplasm of cells in OSCC cell lines and biopsy specimens. Furthermore, Notch pathway inhibition using a Á-secretase inhibitor prevented the growth of OSCC in vitro. These findings suggest that inhibition of the Notch pathway suppresses OSCC growth and may be a useful approach for thetreatment of patients with OSCC. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : International Journal of Oncology 巻 36, 号 4, p. 817-822, 発行日 2010 |
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| 作成日 | ||||||
| 日付 | 2010-04-01 | |||||
| 日付タイプ | Issued | |||||
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| 収録物識別子タイプ | PISSN | |||||
| ISSN | 10196439 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.3892/ijo_00000558 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 496.8 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| 出版者言語 | en | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.spandidos-publications.com/ijo/36/4/817 | |||||
