{"_buckets": {"deposit": "1f8ce85c-c69c-44e3-8ff6-4c4a2ab20dc5"}, "_deposit": {"created_by": 3, "id": "3061", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "3061"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00003061", "sets": ["80"]}, "author_link": ["117881", "15489", "117882"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Functional analysis of an oncogene SnoN as atarget molecule to regulate progresion of osteoarthritis."}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "ガン カンレン タンパク スノーエヌ ノ ヘンケイセイ カンセツショウ セイギョ ヒョウテキ ブンシ トシテノ キノウ カイセキ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2014-06-10"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23592221　研究代表者：前田真吾（鹿児島大学・医歯（薬）学総合研究科・准教授）", "subitem_description_type": "Other"}, {"subitem_description": "変形性関節症（OA）は、患者の活動性を奪い、生命をも脅かしうるロコモティヴ・シンドロームの主因である。その抑制機構としてTGF-βシグナルに注目し、その下流で誘導されるSnoNについて治療標的分子としての可能性について検討した。関節軟骨細胞は分化進行を止めているが、OAでは異常に分化成熟が起こる。SnoNは正常関節軟骨には発現せず、軟骨細胞が肥大成熟すると発現し、OA軟骨で誘導されていた。SnoNが軟骨細胞分化を進めるBMPシグナルを抑制する事で、結果として軟骨細胞成熟を抑制する事が分かった。SnoNの機能を強めるとTGF-β添加と同じ結果になったので、OA予防・治療の標的と成りうる。", "subitem_description_type": "Other"}, {"subitem_description": "Osteoarthritis (OA) suppresses activity of patients, which conditions often lead patients to death. Loss of TGF-beta signaling in mice promotes hypertrophic maturation of chondrocytes in articular cartilage, the phenotype of OA. Among the downstream molecules of TGF-beta signaling, we focused on SnoN to examine its roles in chondrocyte maturation and pathogenesis of OA. SnoN was not expressed in human normal articular cartilage or immature chondrocytes of mice, while it was detected in human OA cartilage as well as in matured mouse chondrocytes. During BMP-induced chondrogenesis in vitro, SnoN suppressed BMP signaling to inhibit the chondrocyte maturation. Gain-of-function of SnoN mimicked the effects of TGF-beta application, therefore, SnoN was suggested to be a novel molecular target in treatment or prevention of OA.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117881", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "マエダ, シンゴ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117882", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "MAEDA, Shingo"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "494", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "23592221"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "前田, 真吾"}], "nameIdentifiers": [{"nameIdentifier": "15489", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000060353463", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "23592221_前田真吾.pdf", "filesize": [{"value": "200.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 200700.0, "url": {"label": "23592221_前田真吾.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/3061/files/23592221_前田真吾.pdf"}, "version_id": "fbe3ef3e-a89a-436d-8315-647612838fe3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "変形性関節症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TGF-β", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SnoN", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "癌関連蛋白スノーエヌの変形性関節症制御標的分子としての機能解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "癌関連蛋白スノーエヌの変形性関節症制御標的分子としての機能解析"}]}, "item_type_id": "8", "owner": "3", "path": ["80"], "permalink_uri": "http://hdl.handle.net/10232/24138", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-05-22"}, "publish_date": "2015-05-22", "publish_status": "0", "recid": "3061", "relation": {}, "relation_version_is_last": true, "title": ["癌関連蛋白スノーエヌの変形性関節症制御標的分子としての機能解析"], "weko_shared_id": 3}