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Synovial cells express thymidine phosphorylase in inflammatory and neoplastic synovial tissue
http://hdl.handle.net/10232/8981
http://hdl.handle.net/10232/8981357790ba-bd78-4800-9b5e-e5ad98f81ef7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DC2001(Hasui).pdf (4.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-05 | |||||
| タイトル | ||||||
| タイトル | Synovial cells express thymidine phosphorylase in inflammatory and neoplastic synovial tissue | |||||
| タイトル言語 | en | |||||
| 著者 |
Hasui, Kazuhisa
× Hasui, Kazuhisa× Sakae, Kiyohiro× Akiyama, Shin-Ichi× Tsuyama, Shin-Ichiro× Hayata, Takashi× Izumo, Shuji× Yonezawa, Suguru× Murata, Fusayoshi× Sato, Eiichi |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Synovial cells | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | thymidine phosphorylase | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | rheumatoid arthritis | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | giant cell tumor | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Synovial cells (SCs) in pathological conditions of synovial tissue were analyzed by means of paraffin-immunohistochemistry in points of immunological phenotypes，which are usually expressed in monocytes/macrophages and dendritic cells. Paraffin sections of 4 cases of non-inflammatory and non-neoplastic synovial tissue, each 1 case of non-specific chronic synovitis and of granulomatous synovitis, 5 cases of rheumatoid arthritis (RA), and 1 case of benign giant cell tumor (GCT) were used. SCs in non-inflammatory and non-neoplastic synovial tissue revealed weak or strong immunoreactivity with CD68 and LN-3 (Ia-like antigen) but did not with thymidine phosphorylase (TP). SCs in RA expressed strong immunoreactivity with TP. GCT tumor cells showed strong immunoreactivity with CD68, LN-3 and TP. T- and B-cell lymphoproliferative lesions were noted in RA，whereas T-cell-dominated one was seen in the other conditions. Germinal centers (GCs) in RA associated some CD3-positive T-cells. Consequently, it was recognized that SCs are of monocytes/macrophage lineage. In pathological conditions SCs expressed TP especially in RA. The expression of TP in SCs in RA suggested non-neoplastic genetic alteration in the expression of TP in the pathological conditions. The unusual expression of TP may induce unusual lymphoproliferative lesion in RA. But the expression of TP in GCT might be as a tumor growth inhibitory factor. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Dendritic cells 巻 11, p. 9-12, 発行日 2001-01-01 |
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| 作成日 | ||||||
| 日付 | 2001-01-01 | |||||
| 日付タイプ | Issued | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA11039557 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NII subject | ||||||
| 主題言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 日本樹状細胞研究会 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Japanese Dendritic Cells Society | |||||
| 出版者言語 | en | |||||
