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肝細胞癌におけるHigh mobility group box-1（HMGB1）発現の意義
http://hdl.handle.net/10232/14449
http://hdl.handle.net/10232/14449b6a717d7-c370-4c48-bed0-49c3615721f6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00040104_v62n3_p27-35.pdf (1.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-07-03 | |||||
| タイトル | ||||||
| タイトル | Significance of High Mobility Group Box-1 (HMGB1) Expression in Hepatocellular Carcinoma | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 肝細胞癌におけるHigh mobility group box-1（HMGB1）発現の意義 | |||||
| タイトル言語 | ja | |||||
| 著者 |
上野, 真一
× 上野, 真一× 樋渡, 清司× 迫田, 雅彦× 飯野, 聡× 蔵原, 弘× 南, 幸次× 安藤, 慶× 前村, 公成× 又木, 雄弘× 松本, 正隆× 大脇, 哲弘× 北薗, 正樹× 石神, 純也× 新地, 洋之× 夏越, 祥次 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular carcinoma (HCC) | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | high mobility group box-1 (HMGB1) | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | reverse transcription-polymerase chain reaction (RT - PCR) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: High mobility group box-1 (HMGB1) induces the release of proinflammatory cytokines and chemokines as a late-acting mediator of inflammation. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer, however, little is known about the relationship between HCC and HMGB1 and its receptor RAGE (receptor for advanced glycation end products). We studied the clinicopathological relevance of the expression level of HMGB1 and the effect of HMGB1 expression on the characteristics of HCC. Methods: Samples from the 36 HCC patients including 7 with positive hepatitis B surface antigen and 21 with hepatitis C antibody were studied. Twenty-four patients had chronic active hepatitis and 4 had liver cirrhosis. The expression of HMGB1 was assessed in paired cancerous and noncancerous tissues with HCC, using reverse-transcription polymerase chain reaction (RT-PCR), and Western blotting. Quantitative RT-PCR data were analyzed relation to clinicopathological features. As a control study, 7 normal liver samples were collected from patients other than HCC. Results: The expression of HMGB1 mRNA was lower in normal liver than in noncancerous tissue and the highest in HCC, although the differences were not significant. Furthermore, in HCC, it was high in well- and moderately differentiated tumors but declined as tumors dedifferentiated to poorly differentiated HCC (p=0.033). The expression level was inversely correlated with tumor recurrence (p=0.036). No significant correlations were observed between the expression levels and well-known prognostic factors of HCC (e.g. portal invasion and intrahepatic metastasis). Conclusion: In HCC, HMGB1 expression level correlated inversely with the patient’s prognosis. The HMGB1 mRNA expression level is similar to the level we reported previously in a study on the clinicopathological relevance of the level of RAGE in HCC. RAGE-HMGB1 interaction in HCC might work in the early stage of tumorigenesis more than in the stage of cancer development. |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
ja : 鹿児島大学医学雑誌 en : Medical journal of Kagoshima University 巻 62, 号 3, p. 27-35, 発行日 2011-01-01 |
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| 作成日 | ||||||
| 日付 | 2011-01-01 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 03685063 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AN00040104 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 494 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
