{"_buckets": {"deposit": "21df968c-3a30-449e-a002-a30b37c6ff32"}, "_deposit": {"created_by": 3, "id": "5096", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "5096"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00005096", "sets": ["80"]}, "author_link": ["117906", "7040", "117905"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "An interrelation among regulatory mechanisms of cardiac Ca2+ channels"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "シンキン Ca チャネル ノ チョウセツ キコウ カン ソウゴ サヨウ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2012-05-31"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(B)))研究成果報告書　課題番号：21390059　研究代表者：亀山正樹 (鹿児島大学大学院医歯学総合研究科教授)", "subitem_description_type": "Other"}, {"subitem_description": "Ｌ型CaチャネルのCaMおよびリン酸化による調節について検討した。CaMはチャネルＣ末部のpreIQとIQ領域に１分子ずつ結合した。PKAによるリン酸化部位は、既存のSer1927（モルモット）に加えて、Ser1574とSer1626とが新たに判明した。CaMKIIによるPreIQ領域にあるThr1603のリン酸化によりCaM作用が増強され、両調節機構の間にクロストークが存在することが判明した。", "subitem_description_type": "Other"}, {"subitem_description": "We investigated regulation of L-type Ca2+ channels by calmodulin (CaM) and phosphorylation. CaM bound to preIQ and IQ regions in the C-terminal of the channel. PKA phosphorylated Ser1574 and Ser1626 as well as Ser1927 (guinea-pig). The facilitatory effect of CaM was enhanced by CaMKII-mediated phosphorylation of Thr1603, suggesting a cross-talk between the CaM’s effect and channel phosphorylation.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117905", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "カメヤマ, マサキ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117906", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "KAMEYAMA, Masaki"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "21390059"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "亀山, 正樹"}], "nameIdentifiers": [{"nameIdentifier": "7040", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000060150059", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "21390059seika.pdf", "filesize": [{"value": "200.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 200700.0, "url": {"label": "21390059seika.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/5096/files/21390059seika.pdf"}, "version_id": "6b049ad1-9ca5-426b-8cc5-98ed20b978c3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "生体膜", "subitem_subject_scheme": "Other"}, {"subitem_subject": "チャネル", "subitem_subject_scheme": "Other"}, {"subitem_subject": "シグナル伝達", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "心筋Caチャネルの調節機構間相互作用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "心筋Caチャネルの調節機構間相互作用"}]}, "item_type_id": "8", "owner": "3", "path": ["80"], "permalink_uri": "http://hdl.handle.net/10232/14693", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-12-22"}, "publish_date": "2014-12-22", "publish_status": "0", "recid": "5096", "relation": {}, "relation_version_is_last": true, "title": ["心筋Caチャネルの調節機構間相互作用"], "weko_shared_id": 3}