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ソテツ種子含有配糖体(Cycasin)による実験的肝癌
http://hdl.handle.net/10232/15902
http://hdl.handle.net/10232/1590276d1b597-94b7-4b69-afc9-e672e85e55ff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN10030752_v6_p1-23.pdf (10.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-06-08 | |||||
| タイトル | ||||||
| タイトル | ソテツ種子含有配糖体(Cycasin)による実験的肝癌 | |||||
| タイトル言語 | ja | |||||
| タイトル | ||||||
| タイトル | Hepatic Cancer of Rats Induced by Cycasin | |||||
| タイトル言語 | en | |||||
| 著者 |
小林, 昭
× 小林, 昭× 寺師, 慎一 |
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| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Although the seeds of cycad plants have been used as a food in southern areas in Japan, people have known that it was toxic without adequate removal of the toxin. The toxin in Japanese Cycas revoluta Thunb. was isolated and the structure of the toxin was elucidated as Cycasin, methylazoxymethyl - β - D-glucoside, by Nishida, Kobayashi and Nagahama in 1955. Laqueur et al. (1963) found that the cycad seeds in Guam had carcinogenic actions in experimental animals through his studies about persumed relationship between ingestion of cycad seeds and neurogenic disorders in men and cattle. The results of many studies indicated that the toxicity and the carcinogenicity of Cycasin were revealed after the enzymatic hydrolysis of Cycasin to the aglycon (Methylazoxymethanol) and that this conversion was brought about in vivo by the action of β -glucosidase, most likely of intestinal bacterial origin. Studies about carcinogenic action of Cycasin and morphological studies on hepatic cancer were carried out in two age-groups of Sprague-Dawley strain rats induced given 10mg/kg body weight of Cycasin in drinking water through experimental periods. Fourteen cases each of hepatic cancer were observed in both sexes (17 females and 16 males) in 21-day-old group of animals between 167 and 487 experimental days in female rats, and between 203 and 438 in male rats. In 50-day-old (20 rats each in both sexes), 18 each of hepatic cancer were observed between 251 and 556 in female rats, and between 280 and 556 in male rats. Macroscopic findings of hepatic tumors were graysh-white nodules with focal hemorrhagic lesions. Macroscopically, most of hapatoma were composed of well differentiated type of hepatocellular carcinoma with trabecular pattern of the tumor cells. And clear cell type of adenocarcinoma, intestinal metalasia type of cancer and pleomorphic cell carcinoma were also observed, but these types of cancer were rare cases. Some cases had sarcomatous pattern of tumor growth. Only one case had liver cirrhotic changes with well differentiated type of hepatoma. Electronmicroscopic findings of tumor cell, such as peroxsomes, tight junctions and bile ductlesses between the tumor cells, suggested that most of the tumor were hepatic cell origin. |
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| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 小林昭（鹿児島大学農学部農芸化学科） | |||||
| 内容記述言語 | ja | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 寺師慎一（鹿児島大学南方海域研究センター） | |||||
| 内容記述言語 | ja | |||||
| 収録雑誌名 |
ja : 南方海域調査研究報告 en : Occasional Papers 巻 6, p. 1-23, 発行日 1986-03-20 |
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| 作成日 | ||||||
| 日付 | 1986-03-20 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 02892707 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AN10030752 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15898 | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15899 | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15900 | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15901 | |||||
| 関連（isVersionOf） | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15897 | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | Title page: http://hdl.handle.net/10232/15897, 序文: http://hdl.handle.net/10232/15898, 開会の辞: http://hdl.handle.net/10232/15899, 主旨説明: http://hdl.handle.net/10232/15900, 目次: http://hdl.handle.net/10232/15901 | |||||
