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ウイルス性肝炎の疫学,臨床と病理
http://hdl.handle.net/10232/15903
http://hdl.handle.net/10232/159036ac7f2f8-b2c4-47fa-8672-383e925cf7e0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN10030752_v6_p25-47.pdf (8.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-06-08 | |||||
| タイトル | ||||||
| タイトル | ウイルス性肝炎の疫学,臨床と病理 | |||||
| タイトル言語 | ja | |||||
| タイトル | ||||||
| タイトル | Hepatitis Viruses and Liver Diseases | |||||
| タイトル言語 | en | |||||
| 著者 |
志方, 俊夫
× 志方, 俊夫 |
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| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Viral hepatitis of human being is caused by the various types of hepatitis viruses, such as hepatitis A virus, B virus, δ virus and unknown non-A, non-B hepatitis viruses. Although those viruses belong respectivelly different virus groups, (some one is RNA virus and the other one is DNA virus) the clinical symptoms and histological features of the liver of each viral hepatitis are quite similar. However, there is some difference among liver diseases caused by each virus. Hepatitis A virus and Indian type non-A, non-B virus only cause acute hepatitis by transient infection. On the contrary, hepatitis B virus and other non-A, non-B viruses cause not only acute hepatitis but also various liver diseases, such as chronic hepatitis, liver cirrhosis and hepatocellular carcinoma due to persistent infection. The incidence of type A hapatitis markedly decreased after World War II in Japan. Whereas, it is still prevalent in South-Asia, Africa and Middle and South-America. Infection of hepatitis A virus is taken place by fecal-oral route. However, there is no evidence for proliferation of this virus in the gut. Hepatitis A virus is only found in the liver, especially in the hepatocytes in the early stage and in the Kupffer cells in the late stage. The spectrum of the clinical and pathological features caused by hepatitis B virus is unusually broad, it also causes chronic hepatitis, liver cirrhosis, healthy carrier and probably hepatocellular carciuoma due to persistent infection. Recently integration of hepatitis B virus genome into cancer cells of the hepatocellular carcinoma was confirmed by Southern blot hybridization method. Furthermore, several quite similar viruses with hepatitis B virus (hepadna viruses) were disclosed in different animal species, such as woodchuck, Pekin duck, grand squirrel etc. and those virues also cause chronic hepatitis and hepatocellular carcinoma in each animal species. |
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| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hepatitis B virus and other hepadna viruses are found mainly in the blood. Therefore, transmission route of those viruses is quite different from hepatitis A virus. Transmission is caused by parenteral routes, such as blood transfusion, intimate contact including sexual intercoures, vertcal transmission at birth. Difference of clinical coures and liver diseases caused by hepatitis B virus mainly depend on the age at which hepatitis B virus infects each persons. Infection in early life, such as newborn or infant usually does not cause acute hepatitis and cause chronic persistent infection. Some of those hepatitis B virus carriers later develop liver cirrhosis and hepatocellular carcinoma. Whereas, if immunologically competent adults are infected with hepatitis B virus, they develop acute hepatitis and later do not develop chronic hepatitis or liver cirrhosis. Concerning non-A, non-B hepatitis, causative viruses are not yet disclosed. Chimpanzee have a susceptibility for those viruses. Hepatocyes of the infected chimpanzees show characteristic ultramicroscopical features. Recently we developed monoclonal antibody specific for non-A, non-B hepatitis by mean of EB virus transformation method of B lymphocytes of convalescent chimpanzee. |
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| 内容記述言語 | en | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 志方俊夫（日本大学医学部病理学講座・長崎大学熱帯医学研究所防疫部門） | |||||
| 内容記述言語 | ja | |||||
| 収録雑誌名 |
ja : 南方海域調査研究報告 en : Occasional Papers 巻 6, p. 25-47, 発行日 1986-03-20 |
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| 作成日 | ||||||
| 日付 | 1986-03-20 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 02892707 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AN10030752 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15898 | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15899 | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15900 | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15901 | |||||
| 関連（isVersionOf） | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/10232/15897 | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | Title page: http://hdl.handle.net/10232/15897, 序文: http://hdl.handle.net/10232/15898, 開会の辞: http://hdl.handle.net/10232/15899, 主旨説明: http://hdl.handle.net/10232/15900, 目次: http://hdl.handle.net/10232/15901 | |||||
