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ラット脳腫瘍モデルを用いた硼素中性子捕捉療法における重水の効用に関する研究
https://doi.org/10.11501/3102436
https://doi.org/10.11501/3102436663a2df9-f56a-4958-86cd-79d5fcd0329f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
000000286307.pdf (7.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-30 | |||||
| タイトル | ||||||
| タイトル | ラット脳腫瘍モデルを用いた硼素中性子捕捉療法における重水の効用に関する研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | An Experimental Study on the Effects of Heavy Water on the Boron Neutron Capture Therapy in a Rat Glioma Model | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | ラット ノウシュヨウ モデル オ モチイタ ホウソ チュウセイシ ホソク リョウホウ ニオケル ジュウスイ ノ コウヨウ ニ カンスル ケンキュウ | |||||
| 言語 | ja-Kana | |||||
| 著者 |
榊, 正剛
× 榊, 正剛 |
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| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Boron neutron capture therapy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | rat C6 glioma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | rat 9L gliosarcoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | heavy water | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| ID登録 | ||||||
| ID登録 | 10.11501/3102436 | |||||
| ID登録タイプ | JaLC | |||||
| 要約(Abstract) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Heavy water in tissues may influence on the effects of boron neutron capture therapy (BNCT). If light water is replaced with heavy water in tissues， boron containing compounds and the other drugs might remain in the tumor tissues for a longer time. A neutron beam seems to penetrate deeper through the heavy water than through the light water in biological tissues. Therefore， the author had experimented on the rat C6 glioma with boron neutron capture therapy after the animals had been given heavy water in place of their normal water supply and furthermore experimentally the effect of heavy water has been investigated. 1. BNCT with heavy water. The investigation was carried out in Wistar albino rats weighing approximately 300g at the begining of the experiment. A thermal neutron fluence of 1.0x10^13 neutrons/cm^2 was planned. In the first experiment，1.0x10^5 cells were implanted stereotactically into the right caudate nucleus of four rats. Two weeks later，the author brought these rats to the Musashi Atomic Energy Research Laboratory. These rats were set on an acryl plate in the prone position after pentobarbital anesthesia. They were put into aluminum cans covered with a thin lead sheet to protect their bodies from the gamma ray contamination of the beam. The thickness of cans was 3mm. On the other hand，their restricted heads were exposed in the thermal neutron irradiation field. Two days after irradiation， these rats were sacrificed and coronal sections of brains were cut down. The specimens were stained with Hematoxylin-Eosin and examined histopathologically. In the second experiment，all rats were fed heavy water orally on demand for two days before irradiation and injected with 50μg/g-body weight boron compounds into the peritoneal cavity six hours before irradiation. The doses of thermal neutron in these two sequential experiments were determined by activation of gold foils set at the back of the rats' heads. The doses were 8.41x10^12 neutrons/cm^2 and 1.17x10^13 neutrons/cm^2 respectively，and were satisfactorily close to our initially anticipated fluence. The gamma ray dose was 156.1 rad on the body and 375.6 rad on the head of the animal. Histological findings in the first experiment were that three of four rats showed advanced tumor growth. On the other hand，only one rat in the second group showsd tumor growth and intratumoral necrosis. 2. Pharmacokinetic study on boron compound with heavy water. The investigation was carried out in Fisher rats weighing 150-200g at the begining of the experiment. 4.0x10^5 rat 9L gliosarcoma cells were implanted into the subcutaneous region of the right latus. 8 rats (group A) were injected with heavy water into the peritoneal cavity everyday for 5 days. 6 rats (group B) were injected with light water. On the 6th day, 100μg/g-body weight boron compounds (BSH) was injected into the peritoneal cavith of all rats. 4 rats of A group and 3 rats of B group were sacrified on 6 hours after boron injcction. Other rats were sacrified on 12 hours after boron injection. Boron concentration in brain tissue and blood and tumor tissue were calculated. Boron concentration in tumor tissue was higher in A group than in B group. Such an experimental results might be contributory to clinical application of boron neuton capture therapy of brain tumors in near future. |
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| 言語 | en | |||||
| 要約(Abstract) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 医歯学総合研究科博士論文(医学) ; 学位取得日: 平成7年3月14日 | |||||
| 言語 | ja | |||||
| 収録雑誌名 |
ja : 鹿児島大学医学雑誌 en : Medical journal of Kagoshima University 巻 46, 号 3, p. 85-93, 発行日 1995 |
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| 作成日 | ||||||
| 日付 | 1995-03-14 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0368-5063 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00040104 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 494 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | カゴシマ ダイガク | |||||
| 言語 | ja-Kana | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 言語 | en | |||||
| 関連（relation）（relationType設定なし） | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://id.ndl.go.jp/bib/000000286307 | |||||
| 関連（isVersionOf） | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://dl.ndl.go.jp/info:ndljp/pid/3102436 | |||||
| 備考 | ||||||
| 値 | 平成22年度に行われた国立国会図書館の学位論文（博士）デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用（全文複写提供、公衆送信）に供することの許諾を受けたものです（参考：http://www.ndl.go.jp/jp/aboutus/digitization_theses.html）。 | |||||
| 学位記番号 | ||||||
| 値 | 医研第316号 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1995-03-14 | |||||
