{"_buckets": {"deposit": "ebb81fab-74c7-483c-aa33-2585c1649723"}, "_deposit": {"created_by": 3, "id": "8121", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "8121"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00008121", "sets": ["79"]}, "author_link": ["112820", "39043", "112821"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Amyloid beta-42-mimotope displaying M13 bacteriophage for vaccine vehicle of Alzheimer’s disease"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "アルツハイマー ニンチショウ ノ ワクチン ブンシ セッケイ ニ カンスル キソ ケンキュウ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2012-06-12"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(B)))研究成果報告書　課題番号：21310144　研究代表者：杉村和久 (鹿児島大学大学院理工学研究科(工学系)教授)", "subitem_description_type": "Other"}, {"subitem_description": "本研究で確立したアミロイドベーター42繊維特異ヒト抗体、B6とB7のエピトープ解析から明らかになったアミロイドベーター42繊維のミミックペプチド、B6-C15を提示するM13ファージをワクチンとして用い、能動免疫によるアルツハイマー認知症の病態マウスモデル(J20)について解析した。その結果、ファージ１匹あたり５分子しか提示されていない状況下（g3p提示）でも、C57BL/Jマウスの皮下検疫により、アミロイドベーター42の繊維および可溶性オリゴマーに反応する特異的抗体が誘導される事を明らかにした。", "subitem_description_type": "Other"}, {"subitem_description": "Bacteriophage evokes strong antibody production by means of innate immunity. Recently, we have established B6 mimotope peptide (B6-C15) which mimics the structure of amyloid ・ 42 (A・) fibril using human single-chain Fv (B6) specific to A・42 fibril. This mimotope peptide binds to A・42 oligomers and inhibits formation of A・42 fibril in vitro. We investigated whether M13 bacteriophage displaying B6-mimotope peptide (B6-C15-phage) could produce A・42 fibril specific antibody response in mice. When mice were immunized i.p. with B6-C15-phage in PBS solution, they produced anti-A・42 fibril specific IgG response in two weeks. This finding suggested a promising vaccination strategy for immunotherapy of Alzheimer’s disease without the involvement of A・42-specific T cell immunity (BBRC 402: 19-22, 2010, and J. Neuroimmunol. 236: 27-38, 2011).", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "112820", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "スギムラ, カズヒサ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "112821", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "SUGIMURA, Kazuhisa"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "21310144"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "杉村, 和久"}], "nameIdentifiers": [{"nameIdentifier": "39043", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000080127240", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "21310144seika.pdf", "filesize": [{"value": "177.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 177600.0, "url": {"label": "21310144seika.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/8121/files/21310144seika.pdf"}, "version_id": "7cd2e023-d6fa-44d9-b123-33b7253c6380"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "アルツハイマー認知症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "M13 ファージ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ワクチン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "自然免疫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ミミックペプチド", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アミロイドベーター", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "アルツハイマー認知症のワクチン分子設計に関する基礎研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "アルツハイマー認知症のワクチン分子設計に関する基礎研究"}]}, "item_type_id": "8", "owner": "3", "path": ["79"], "permalink_uri": "http://hdl.handle.net/10232/14687", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-12-22"}, "publish_date": "2014-12-22", "publish_status": "0", "recid": "8121", "relation": {}, "relation_version_is_last": true, "title": ["アルツハイマー認知症のワクチン分子設計に関する基礎研究"], "weko_shared_id": 3}