{"_buckets": {"deposit": "19b4d0bd-25e9-47aa-be17-0749b8235fdb"}, "_deposit": {"created_by": 3, "id": "8133", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "8133"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00008133", "sets": ["80"]}, "author_link": ["39082", "117976", "117975"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Role of Wnt-5a signaling in tumors"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "シュヨウ ノ ビョウタイ ニオケル Wnt シグナル ノ ヤクワリ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2012-05-31"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21590341　研究代表者：岸田昭世 (鹿児島大学大学院医歯学総合研究科教授)", "subitem_description_type": "Other"}, {"subitem_description": "ヒトグリオーマ（神経膠腫）由来の細胞株におけるすべてのWntファミリーの発現を解析し、Wnt-5Aの有意な発現の亢進を認め、Wnt-5A発現亢進がグリオーマの細胞運動、MMP-2発現調節を解して浸潤能を調節していることを見出した。また、がん化に関わる可能性があるHPVやSV40ウイルスを使わずにヒト正常口腔上皮由来細胞MOE1の樹立に成功し、これらの細胞株でWnt-5Aが発現していることを見出した。以上のことから鑑みて、当初の計画以上に進展していると判断している。", "subitem_description_type": "Other"}, {"subitem_description": "We analyzed the expressions of all Wnts and Frizzleds in several human glioma cell lines and found that Wnt-5A, Wnt-7A, Frizzled-2, and Frizzled-6 were highly expressed in those cells. By Wnt-5A-knockdown experiment, we have shown that Wnt-5A stimulated induced cellular motility and invasion of human glioma cells through the induction of MMP-2 mRNA expression and MMP-2 enzymatic activity. We established normal human epithelial cells without using HPV and SV40 genes, which have the potential to induce carcinogenesis.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117975", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "キシダ, ショウセイ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117976", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "KISHIDA, Shosei"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "21590341"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岸田, 昭世"}], "nameIdentifiers": [{"nameIdentifier": "39082", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000050274064", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "21590341seika.pdf", "filesize": [{"value": "192.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 192400.0, "url": {"label": "21590341seika.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/8133/files/21590341seika.pdf"}, "version_id": "4a71c277-c54e-4368-bcd2-76fae28fd470"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Wnt", "subitem_subject_scheme": "Other"}, {"subitem_subject": "シグナル伝達", "subitem_subject_scheme": "Other"}, {"subitem_subject": "脳腫瘍", "subitem_subject_scheme": "Other"}, {"subitem_subject": "グリオーマ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "口腔上皮", "subitem_subject_scheme": "Other"}, {"subitem_subject": "不死化", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "腫瘍の病態におけるWntシグナルの役割", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "腫瘍の病態におけるWntシグナルの役割"}]}, "item_type_id": "8", "owner": "3", "path": ["80"], "permalink_uri": "http://hdl.handle.net/10232/14727", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-12-22"}, "publish_date": "2014-12-22", "publish_status": "0", "recid": "8133", "relation": {}, "relation_version_is_last": true, "title": ["腫瘍の病態におけるWntシグナルの役割"], "weko_shared_id": 3}