{"_buckets": {"deposit": "3c97782e-0197-408c-998d-8171b8483838"}, "_deposit": {"created_by": 3, "id": "9006", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "9006"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00009006", "sets": ["80"]}, "author_link": ["2140", "118031", "118032"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Search of organ specific tumor makers by N-glycan expression"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "Nガタ トウサ オ モチイタ ゾウキ トクイテキ シュヨウ マーカー ノ カイハツ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2014-06-11"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2012-2013年度科学研究費助成事業（挑戦的萌芽研究）研究成果報告書　課題番号：24659618　研究代表者：夏越祥次（鹿児島大学・医歯（薬）学総合研究科・教授）", "subitem_description_type": "Other"}, {"subitem_description": "健常者11検体と食道がん患者63検体をGlycoModも用いて糖鎖構造の中から18糖鎖を選択した。これらの18糖鎖による多変量解析を行い、有意差が認められた糖鎖を4つ抽出した。このうち3つは、過去に行ったMALDI-TOF-MSで抽出された糖鎖構造と一致し、新たに1つの糖鎖が発見された。これらの糖鎖は食道癌に特異的で精度の高い糖鎖マーカーとして利用できると考えられた。また、健常者群と膵臓癌患者群間で、両者の層別化が可能な発現糖鎖が9つ抽出可能であった。4個の候補糖鎖で有意差が認められ、再現性が確認された。膵臓癌に特異的な糖鎖マーカーとしてさらに症例を増やして検討する必要がある。", "subitem_description_type": "Other"}, {"subitem_description": "We analyzed the serum  N-glycan by Profiling Solution in 63 esophageal cancer patients and 11 healthy volunteers. We selected 18  N-glycan by GlycoMod method. When performing by multivariate analysis in these N-glycan, 4 glycan had a significant difference. Three of these four N-glycan was in accord with structure of N-glycan which was previously extracted by MALDI-TOF-MS method. Thus new one N-glycan was found. These N-glycans are useful markers to detect esophageal cancer. In pancreas cancer, we found 9 N-glycans which was stratified between esophageal cancer patients and healthy volunteers. In four of these 9 N-Glycans, significant difference was identified. We should collect many cases and analyze the useful markers for detection of pancreas cancer.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118031", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ナツゴエ, ショウジ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118032", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "NATSUGOE, Shoji"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "24659618"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "夏越, 祥次"}], "nameIdentifiers": [{"nameIdentifier": "2140", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000070237577", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "24659618_夏越祥次.pdf", "filesize": [{"value": "203.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 203600.0, "url": {"label": "24659618_夏越祥次.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/9006/files/24659618_夏越祥次.pdf"}, "version_id": "419f9f36-6ec6-419b-9d09-3f378a9db24c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "消化器癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "N結合型連鎖", "subitem_subject_scheme": "Other"}, {"subitem_subject": "食道癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "膵臓癌", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "N型糖鎖を用いた臓器特異的腫瘍マーカーの開発", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "N型糖鎖を用いた臓器特異的腫瘍マーカーの開発"}]}, "item_type_id": "8", "owner": "3", "path": ["80"], "permalink_uri": "http://hdl.handle.net/10232/24063", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-05-21"}, "publish_date": "2015-05-21", "publish_status": "0", "recid": "9006", "relation": {}, "relation_version_is_last": true, "title": ["N型糖鎖を用いた臓器特異的腫瘍マーカーの開発"], "weko_shared_id": 3}