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Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region
http://hdl.handle.net/10232/3738
http://hdl.handle.net/10232/37382b010c0a-ebbe-47ff-8ab1-6b03465b4743
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DC(Hasui)1994.pdf (3.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-04-13 | |||||
| タイトル | ||||||
| タイトル | Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region | |||||
| 言語 | en | |||||
| 著者 |
Hasui, Kazuhisa
× Hasui, Kazuhisa× Sato, Eiichi |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Human T-cell leukemia virus type 1(HTLV-1) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Malignant lymphomas | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | HTLV-1 endemic area | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | In-situ-hybridization | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | HTLV-l pX Tax | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約(Abstract) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This study aimed to see HTLV-1 infection in 277 cases of malignant lymphoma (ML) in a HTLV-1indemic area by means of ISH employing a highly biotinylated concatamer probe synthesized by a couple of primers SK43 and 44 PCR for HTLV-1 provial DNA pX Tax region. The MLs comprised 115 T-cell MLs, 73 B-cell MLs, 14 Hodgkin's disease (HD) and MLs from the age group less than 20 years old (y.o.). The non-Hodgkin's MLs were categorized according to updated Kiel classification. ISH detected a signal of HTLV-1 proviral DNA including pX Tax region, showing positive stain dominantly in cytoplasm of lymphoma cells and non-neoplastic cells including intermingling small 1ymphocytes, histiocytes and epithelioid cells. ML in which lymphoma cells showed the signal was defined as ""HTLV-1-related ML"". And ML in which any cells revealed the signal was defined as ""HTLV-1-carrier ML"". HTLV-1-related MLs were found in all the subtypes of T-cell MLs (69/115, 60%), indicating its high rate (44/45, 97.8%) in T-cell pleomorphic lymphoma with histological features of adult T-cell leukemia/ lymphoma (ATLL). Even in MLs other than the T-cell MLs, HTLV-1ielated MLs were noted in 21 (29%) of B-cell MLs, 8 (57%) of HD and 4 (16%) of MLs from the age group less than 20 y.o.. HTLV-1-carrier MLs were found in 93 (81%) of T-cell MLs, 35 (49%) of B-cell MLs, 8 (57%) of HD, 13 (52%) of MLs from the age group less than 20 y.o.. HTLV-1-related T-cell MLs in which many lymphoma cells showed the signal may be ATLL, but it was unknown whether there were ATLLs in the ISH-negative cases and in HTLV-1-carrier MLs other than HTLV-1ielated MLs. Considering several technical problems in this ISH, the followings were suggested in this study. HTLV-1 may have oncogenetic effect(s) specific for ATLL and non-specific for MLs other than ATLL but ATLL development would need factor(s) other than HTLV-1 infection. There may be HTLV-1-related B-cell MLs and HD. Some of patients with B-cell MLs and in the under 20-year-old ML patients would fail to produce antibodies against HTLV-1, because higher HTLV-1 carrier rates in these patients were recognized in this study than in the serovirological studies. |
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| 言語 | en | |||||
| 収録雑誌名 |
en : Dendritic cells 巻 4, p. 125-137, 発行日 1994-01-01 |
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| 作成日 | ||||||
| 日付 | 1994-01-01 | |||||
| 日付タイプ | Issued | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11039557 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NIIsubject | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 日本樹状細胞研究会 | |||||
| 言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Japanese Dendritic Cells Society | |||||
| 言語 | en | |||||
