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  1. 医歯学総合研究科
  2. 医歯学総合研究科・学術誌論文

Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region

http://hdl.handle.net/10232/3738
http://hdl.handle.net/10232/3738
2b010c0a-ebbe-47ff-8ab1-6b03465b4743
名前 / ファイル ライセンス アクション
DC(Hasui)1994.pdf DC(Hasui)1994.pdf (3.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-04-13
タイトル
タイトル Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region
タイトル言語 en
著者 Hasui, Kazuhisa

× Hasui, Kazuhisa

WEKO 117227

en Hasui, Kazuhisa

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Sato, Eiichi

× Sato, Eiichi

WEKO 117228

en Sato, Eiichi

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言語
言語 eng
キーワード
主題言語 en
主題Scheme Other
主題 Human T-cell leukemia virus type 1(HTLV-1)
キーワード
主題言語 en
主題Scheme Other
主題 Malignant lymphomas
キーワード
主題言語 en
主題Scheme Other
主題 HTLV-1 endemic area
キーワード
主題言語 en
主題Scheme Other
主題 In-situ-hybridization
キーワード
主題言語 en
主題Scheme Other
主題 HTLV-l pX Tax
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
要約
内容記述タイプ Other
内容記述 This study aimed to see HTLV-1 infection in 277 cases of malignant lymphoma (ML) in a HTLV-1indemic area by means of ISH employing a highly biotinylated concatamer probe synthesized by a couple of primers SK43 and 44 PCR for HTLV-1 provial DNA pX Tax region. The MLs comprised 115 T-cell MLs, 73 B-cell MLs, 14 Hodgkin's disease (HD) and MLs from the age group less than 20 years old (y.o.). The non-Hodgkin's MLs were categorized according to updated Kiel classification. ISH detected a signal of HTLV-1 proviral DNA including pX Tax region, showing positive stain dominantly in cytoplasm of lymphoma cells and non-neoplastic cells including intermingling small 1ymphocytes, histiocytes and epithelioid cells. ML in which lymphoma cells showed the signal was defined as ""HTLV-1-related ML"". And ML in which any cells revealed the signal was defined as ""HTLV-1-carrier ML"". HTLV-1-related MLs were found in all the subtypes of T-cell MLs (69/115, 60%), indicating its high rate (44/45, 97.8%) in T-cell pleomorphic lymphoma with histological features of adult T-cell leukemia/ lymphoma (ATLL). Even in MLs other than the T-cell MLs, HTLV-1ielated MLs were noted in 21 (29%) of B-cell MLs, 8 (57%) of HD and 4 (16%) of MLs from the age group less than 20 y.o.. HTLV-1-carrier MLs were found in 93 (81%) of T-cell MLs, 35 (49%) of B-cell MLs, 8 (57%) of HD, 13
(52%) of MLs from the age group less than 20 y.o.. HTLV-1-related T-cell MLs in which many lymphoma cells showed the signal may be ATLL, but it was unknown whether there were ATLLs in the ISH-negative cases and in HTLV-1-carrier MLs other than HTLV-1ielated MLs. Considering several technical problems in this ISH, the followings were suggested in this study. HTLV-1 may have oncogenetic effect(s) specific for ATLL and non-specific for MLs other than ATLL but ATLL development would need factor(s) other than HTLV-1 infection. There may be HTLV-1-related B-cell MLs and HD. Some of patients with B-cell MLs and in the under 20-year-old ML patients would fail to produce antibodies against HTLV-1, because higher HTLV-1 carrier rates in these patients were recognized in this study than in the serovirological studies.
内容記述言語 en
収録雑誌名 en : Dendritic cells

巻 4, p. 125-137, 発行日 1994-01-01
作成日
日付 1994-01-01
日付タイプ Issued
NII書誌ID(雑誌)
収録物識別子タイプ NCID
NC ID AA11039557
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
NDC
主題Scheme NDC
主題 490
NII subject
主題言語 ja
主題Scheme Other
主題 医学
公開者・出版者
出版者 日本樹状細胞研究会
出版者言語 ja
公開者・出版者
出版者 Japanese Dendritic Cells Society
出版者言語 en
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