{"_buckets": {"deposit": "43bc2d9a-4530-43fb-a17e-8bad6ecf26c6"}, "_deposit": {"created_by": 3, "id": "9835", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "9835"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00009835", "sets": ["78"]}, "author_link": ["117227", "117228"], "item_6_biblio_info_5": {"attribute_name": "収録雑誌名", "attribute_value_mlt": [{"bibliographicPageEnd": "137", "bibliographicPageStart": "125", "bibliographicVolumeNumber": "4", "bibliographic_titles": [{"bibliographic_title": "Dendritic cells"}]}]}, "item_6_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "1994-01-01"}]}, "item_6_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "This study aimed to see HTLV-1 infection in 277 cases of malignant lymphoma (ML) in a HTLV-1indemic area by means of ISH employing a highly biotinylated concatamer probe synthesized by a couple of primers SK43 and 44 PCR for HTLV-1 provial DNA pX Tax region. The MLs comprised 115 T-cell MLs, 73 B-cell MLs, 14 Hodgkin\u0027s disease (HD) and MLs from the age group less than 20 years old (y.o.). The non-Hodgkin\u0027s MLs were categorized according to updated Kiel classification. ISH detected a signal of HTLV-1 proviral DNA including pX Tax region, showing positive stain dominantly in cytoplasm of lymphoma cells and non-neoplastic cells including intermingling small 1ymphocytes, histiocytes and epithelioid cells. ML in which lymphoma cells showed the signal was defined as \"\"HTLV-1-related ML\"\". And ML in which any cells revealed the signal was defined as \"\"HTLV-1-carrier ML\"\". HTLV-1-related MLs were found in all the subtypes of T-cell MLs (69/115, 60%), indicating its high rate (44/45, 97.8%) in T-cell pleomorphic lymphoma with histological features of adult T-cell leukemia/ lymphoma (ATLL). Even in MLs other than the T-cell MLs, HTLV-1ielated MLs were noted in 21 (29%) of B-cell MLs, 8 (57%) of HD and 4 (16%) of MLs from the age group less than 20 y.o.. HTLV-1-carrier MLs were found in 93 (81%) of T-cell MLs, 35 (49%) of B-cell MLs, 8 (57%) of HD, 13 \n(52%) of MLs from the age group less than 20 y.o.. HTLV-1-related T-cell MLs in which many lymphoma cells showed the signal may be ATLL, but it was unknown whether there were ATLLs in the ISH-negative cases and in HTLV-1-carrier MLs other than HTLV-1ielated MLs. Considering several technical problems in this ISH, the followings were suggested in this study. HTLV-1 may have oncogenetic effect(s) specific for ATLL and non-specific for MLs other than ATLL but ATLL development would need factor(s) other than HTLV-1 infection. There may be HTLV-1-related B-cell MLs and HD. Some of patients with B-cell MLs and in the under 20-year-old ML patients would fail to produce antibodies against HTLV-1, because higher HTLV-1 carrier rates in these patients were recognized in this study than in the serovirological studies.", "subitem_description_type": "Other"}]}, "item_6_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "日本樹状細胞研究会"}]}, "item_6_source_id_9": {"attribute_name": "NII書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11039557", "subitem_source_identifier_type": "NCID"}]}, "item_6_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "490", "subitem_subject_scheme": "NDC"}]}, "item_6_subject_20": {"attribute_name": "NIIsubject", "attribute_value_mlt": [{"subitem_subject": "医学", "subitem_subject_scheme": "Other"}]}, "item_6_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Japanese Dendritic Cells Society"}]}, "item_6_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Journal Article"}]}, "item_6_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hasui, Kazuhisa"}], "nameIdentifiers": [{"nameIdentifier": "117227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Eiichi"}], "nameIdentifiers": [{"nameIdentifier": "117228", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DC(Hasui)1994.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "DC(Hasui)1994.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/9835/files/DC(Hasui)1994.pdf"}, "version_id": "16aa7bcc-36a5-4140-8104-e0746214cacc"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Human T-cell leukemia virus type 1(HTLV-1)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Malignant lymphomas", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HTLV-1 endemic area", "subitem_subject_scheme": "Other"}, {"subitem_subject": "In-situ-hybridization", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HTLV-l pX Tax", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region"}]}, "item_type_id": "6", "owner": "3", "path": ["78"], "permalink_uri": "http://hdl.handle.net/10232/3738", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-04-13"}, "publish_date": "2010-04-13", "publish_status": "0", "recid": "9835", "relation": {}, "relation_version_is_last": true, "title": ["Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region"], "weko_shared_id": 3}