{"_buckets": {"deposit": "26319eec-cd88-456c-a3b1-32d0a6da5fe9"}, "_deposit": {"created_by": 3, "id": "1027", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1027"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00001027", "sets": ["83"]}, "author_link": ["6511", "74342", "74343"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Phosphorylcholine Suppresses the Allergic Rhinitis in Mice"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "ネンマク ワクチン ニヨル Iガタ アレルギー ノ ユウドウ キジョ ト ソノ セイギョ ニカンスル ケンキュウ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2013-05-31"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2011-2012年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書　課題番号：23791911　研究代表者：宮下圭一(鹿児島大学・医学部・歯学部附属病院・助教)", "subitem_description_type": "Other"}, {"subitem_description": "マウスのアレルギー性鼻炎モデルを用いて、Th1/Th2バランスおよびアレルギー病態に対するPCの関与について検討した。OVA感作前にPC-BSAを経鼻投与し、アレルギー症状、鼻粘膜への好酸球浸潤、血清IgE値、脾臓のCD4陽性T細胞のサイトカイン産生能を検討した。PC-BSAの経鼻前投与によりくしゃみ、鼻掻き回数が減少し、血清中OVA特異的IgE濃度の低下を認めた。さらに脾臓CD4陽性T細胞のIL-4産生の減少が認められた。これらの結果からマウスのPC前投与のアレルギー性鼻炎に対する抑制効果が示唆され、PCにはTh2型のアレルギー反応を抑制する働きがあると考えられた。", "subitem_description_type": "Other"}, {"subitem_description": "Background: Phosphorylcholine (PC), which is a structural component of wide variety of bacteria. However immunomodulatory properties of PC in the upper respiratory tract have not yet been characterized. Objective: We sought to elucidate the effects of PC on the regulation of allergic response in the upper respiratory tract. Methods: Allergic rhinitis model established by ovalbumin (OVA) sensitization was pretreated by intranasal or peritoneal administration of PC-bovine serum albumin (PC-BSA). Allergic responses were compared with non-pretreated mice. IL-12p40 production by DCs stimulated with PC was measured to evaluate the effect of PC on the TH2 responses mediated by DCs. Results: PC-pretreated mice showed mild allergic nasal symptoms compared to the mice without PC-pretreatment. The levels of total IgE and OVA-specific IgE were significantly lower in PC-pretreated mice. The IL-4 production by splenic CD4+ T cells was down-regulated by PC-pretreatment. Further, PC induced IL-12p40 production by DCs. Conclusion: These findings indicate that PC inhibits the allergic response in the upper respiratory tract mediated by the induction of IL-12p40 production by DCs. Thus, PC might be useful as an immunotherapeutic agent for allergic diseases.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "74342", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ミヤシタ, ケイイチ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "74343", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "MIYASHITA, Kiichi"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "496", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "23791911"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "宮下, 圭一"}], "nameIdentifiers": [{"nameIdentifier": "6511", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000030585063", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "23791911.pdf", "filesize": [{"value": "575.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 575500.0, "url": {"label": "23791911.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/1027/files/23791911.pdf"}, "version_id": "1dad0cee-4b1e-4e8c-a813-975acfe20946"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "粘膜ワクチン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2 バランス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Phosphprylcholine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アレルギー", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "粘膜ワクチンによるⅠ型アレルギーの誘導機序とその制御に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "粘膜ワクチンによるⅠ型アレルギーの誘導機序とその制御に関する研究"}]}, "item_type_id": "8", "owner": "3", "path": ["83"], "permalink_uri": "http://hdl.handle.net/10232/19904", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-01"}, "publish_date": "2013-10-01", "publish_status": "0", "recid": "1027", "relation": {}, "relation_version_is_last": true, "title": ["粘膜ワクチンによるⅠ型アレルギーの誘導機序とその制御に関する研究"], "weko_shared_id": 3}