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Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study
http://hdl.handle.net/10232/14463
http://hdl.handle.net/10232/144631a427213-504b-4574-aa0f-8e94a1cecfb7
名前 / ファイル | ライセンス | アクション |
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AN00040104_v63n3_p59-65.pdf (235.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-07-03 | |||||
タイトル | ||||||
タイトル | Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study | |||||
別言語のタイトル | ||||||
その他のタイトル | Aralar欠損マウスにおける脳内トリプトファン水酸化酵素の発現の減少と不安様行動の減少についての予報 | |||||
著者 |
MATSUMOTO, Yasuhide
× MATSUMOTO, Yasuhide× SHIMOTSU, Kyoko× IIJIMA, Mikio× SAHEKI, Takeyori× NAKAGAWA, Shiro |
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別言語の著者 | ||||||
姓名 | 松元, 泰英 | |||||
別言語の著者 | ||||||
姓名 | 下津, 京子 | |||||
別言語の著者 | ||||||
姓名 | 飯島, 幹雄 | |||||
別言語の著者 | ||||||
姓名 | 佐伯, 武頼 | |||||
別言語の著者 | ||||||
姓名 | 中河, 志朗 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aralar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serotonin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tryptophan hydroxylase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | elevated plus-maze test | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | light-dark exploration test | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Aralar, an isoform of the calcium-binding aspartate-glutamate mitochondrial carrier, is distributed specifically in the brain and skeletal muscles. The aim of the present study was to investigate behaviors induced by the decreased expression of aralar in the brain and to assess whether expression of brain tryptophan hydroxylase, a key enzyme in serotonin synthesis, is correlative with behavioral changes in aralar-deficient mice. In the elevated plus-maze test, heterozygous mice (Aralar^{+/-}) spent more time in the open arms and showed a significant increase in the number of entries to the open arms compared to wild-type littermates (Aralar^{+/+}). In addition, Aralar^{+/-} mice spent more time in the light compartment in a light-dark exploration test compared to Aralar^{+/+} mice. Western blot analysis showed a decreased expression of brain tryptophan hydroxylase in Aralar^{+/-} mice compared to Aralar^{+/+} mice. These results suggested that Aralar^{+/-} mice exhibit a lower level of anxiety-like behaviors compared to Aralar^{+/+} littermates. This might be correlative with the reduced serotonin synthesis. |
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収録雑誌名 |
鹿児島大学医学雑誌=Medical journal of Kagoshima University 巻 63, 号 3, p. 59-65 |
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作成日 | ||||||
日付 | 2012-01-01 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
ISSN | 03685063 | |||||
NII書誌ID(雑誌) | ||||||
収録物識別子タイプ | NCID | |||||
NC ID | AN00040104 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 494 | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University |