{"_buckets": {"deposit": "b869e0a7-cf1b-472d-9666-4bd9cf65d7d9"}, "_deposit": {"created_by": 3, "id": "11587", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "11587"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00011587", "sets": ["80"]}, "author_link": ["118076", "55417", "118077", "24996", "118075", "118078"], "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "TCR-Vβ キョウイテキ ヒトコウタイ オ モチイタ Tサイボウセイ リンパシュ チリョウヤク ノ カイハツ"}, {"subitem_alternative_title": "A study of TCR-Vβ targeted antibody therapy against human T cell lymphoma"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2013-05-16"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2011-2012年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究)研究成果報告書　課題番号：23659286　研究代表者：有馬直道(鹿児島大学・大学院医歯学総合研究科・教授)", "subitem_description_type": "Other"}, {"subitem_description": "施設内研究倫理委員会承認下に、同意を得られたATL患者末梢血白血病細胞のTCRVβのレパトアがVβ2であることを確認。抽出RNAより5’RACE法を用い、TCRのαとβの全長をクローニングし単離した。TCRβの発現ベクターをレンチウイルスベクター系により樹立し、Jurkat細胞株に感染し、TCRβ2の発現系を確立した。同時にヒト抗体重鎖・軽鎖発現ファージライブラリーの構築を、正常ヒトリンパ球RNAをもとに構築した。", "subitem_description_type": "Other"}, {"subitem_description": "Under admission of IRB, repertoire of TCRVb of leukemic cells derived from an ATL patient was demonstrated Vb2. Full length of TCR α and β were separated from extracted RNA by 5’RACE method. TCRb expressing vector was established using lenti-virus bector system, and infected into Jurkat cells which expresses successfully trnsfected TCR2 protein. On the other hands, human anbibody heavy and light chain expressing phage library was constructed using normal health lymphocyte RNA. Using these two materials, we further study establishment of malignant T cell targeted antibody therapy.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118075", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "アリマ, ナオミチ"}]}, {"nameIdentifiers": [{"nameIdentifier": "118076", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "イトウ, ユウジ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118077", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ARIMA, Naomichi"}]}, {"nameIdentifiers": [{"nameIdentifier": "118078", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ITO, Yuji"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "491.5", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "23659286"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "有馬, 直道"}], "nameIdentifiers": [{"nameIdentifier": "55417", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000030175997", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}, {"creatorNames": [{"creatorName": "伊東, 祐二"}], "nameIdentifiers": [{"nameIdentifier": "24996", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000060223195", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "23659286.pdf", "filesize": [{"value": "214.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 214900.0, "url": {"label": "23659286.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/11587/files/23659286.pdf"}, "version_id": "d7f85a90-3a86-4649-b75b-90a1fc294170"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "抗体療法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TCR-Vβ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T細胞性リンパ腫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "治療薬", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "TCR-Vβ特異的ヒト抗体を用いたT細胞性リンパ腫治療薬の開発", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "TCR-Vβ特異的ヒト抗体を用いたT細胞性リンパ腫治療薬の開発"}]}, "item_type_id": "8", "owner": "3", "path": ["80"], "permalink_uri": "http://hdl.handle.net/10232/19883", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-01"}, "publish_date": "2013-10-01", "publish_status": "0", "recid": "11587", "relation": {}, "relation_version_is_last": true, "title": ["TCR-Vβ特異的ヒト抗体を用いたT細胞性リンパ腫治療薬の開発"], "weko_shared_id": 3}