{"_buckets": {"deposit": "1afd4c4e-f0d6-4d00-b19d-60aa5965c6d4"}, "_deposit": {"created_by": 3, "id": "11993", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "11993"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00011993", "sets": ["135"]}, "author_link": ["29942", "106332", "106333"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Impact of hepatitis C virus infection in B cells pathogenesis"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "Cガタ カンエン サイボウ ガ Bサイボウ オ カイシテ ハッキスル ビョウゲンセイ ノ インパクト"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2014-05-29"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23590547　研究代表者：小原恭子（鹿児島大学・獣医学部・教授）", "subitem_description_type": "Other"}, {"subitem_description": "C型肝炎ウイルス（HCV）によるBリンパ腫発症機序を解明するため、B細胞でHCV全長を発現するトランスジェニック（Tg）マウスを用いて解析した。本マウスの約25％でBリンパ腫が発症する。マイクロアレイを用いた網羅的な解析を行った結果、Bリンパ腫発症群では、Fos, C3, Lymphotoxin βR, A20, NF-κBの発現が強く修飾されていた。Bリンパ腫組織ではNF-κBが核に移行して活性化されていることが明らかとなった。さらに、肝がんや肺がんなどでの発現低下も報告され、腫瘍抑制効果があるとされるmiR-26bの発現がBリンパ腫組織では低下している事が明らかとなった。", "subitem_description_type": "Other"}, {"subitem_description": "Hepatitis C virus (HCV) infection leads to the  development of hepatic diseases, as well as extra hepatic disorders such as B-cell  non-Hodikin\u0027s lymphoma  (B-NHL). To reveal the molecular signaling pathways responsible for HCV-associated B-NHL development, we utilized transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-deceloping HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analyzed by genome-wide microarray. Markedly modified genes such as Fos, C3, LTbR, A20, NF-kB and miR-26b in BCLs were further characterized using specific assays. We propose that activation of both canonical and alternative NF-kB signaling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106332", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "コハラ, キョウコ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106333", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "KOHARA, Kyoko"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "493", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "23590547"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小原, 恭子"}], "nameIdentifiers": [{"nameIdentifier": "29942", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000020225478", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "23590547_小原恭子.pdf", "filesize": [{"value": "471.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 471300.0, "url": {"label": "23590547_小原恭子.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/11993/files/23590547_小原恭子.pdf"}, "version_id": "cd3ee869-ccdf-4f79-8327-cc4d29de5269"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "C型肝炎ウイルス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bリンパ腫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microarray", "subitem_subject_scheme": "Other"}, {"subitem_subject": "A20", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NF-kB", "subitem_subject_scheme": "Other"}, {"subitem_subject": "miR-26b", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "C型肝炎細胞がB細胞を介して発揮する病原性のインパクト", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "C型肝炎細胞がB細胞を介して発揮する病原性のインパクト"}]}, "item_type_id": "8", "owner": "3", "path": ["135"], "permalink_uri": "http://hdl.handle.net/10232/24149", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-05-22"}, "publish_date": "2015-05-22", "publish_status": "0", "recid": "11993", "relation": {}, "relation_version_is_last": true, "title": ["C型肝炎細胞がB細胞を介して発揮する病原性のインパクト"], "weko_shared_id": 3}