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エタノールの糖尿病病態への影響：レプチン受容体欠損マウスを用いた検討
http://hdl.handle.net/10232/00030367
http://hdl.handle.net/10232/00030367e70cff55-b029-4349-88f3-7a00152e9871
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00040104_69_p1-8 (912.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-10 | |||||
| タイトル | ||||||
| タイトル | エタノールの糖尿病病態への影響：レプチン受容体欠損マウスを用いた検討 | |||||
| タイトル言語 | ja | |||||
| タイトル | ||||||
| タイトル | Effects of ethanol intake on pathophysiology of diabetes: a study using db mice, an animal model of diabetes with a leptin receptor deficiency | |||||
| タイトル言語 | en | |||||
| 著者 |
牛飼, 美晴
× 牛飼, 美晴× 川口, 博明× 阿部, 正治× 堀内, 正久 |
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| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | diabetes | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | alcohol | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | fatty liver | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | energy intake | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Purpose: We evaluated the influence of ethanol intake on pathophysiology of diabetes using db mice, an animal model of type 2 diabetes. Methods: The concentration of ethanol used was evaluated by the preference test. Then, 6 homozygotes (db) as diabetes and 6 heterozygotes as non-diabetes were used. The mice were randomly separated to water group and ethanol group (5% ethanol was supplied), then they were kept for 9 weeks. Finally, they were anesthetized by after 6 h fasting, and organs were removed after blood collection from the heart. Results: The ethanol concentration used was determined as 5%, which was not discriminated from water by db and control mice. Mice supplied with ethanol showed significantly lower intake of food, which was compensated by the energy from ethanol. dbethanol (EtOH) mice showed lower plasma glucose and HbA1c, indicating that glucose metabolism was not aggravated. On the other hand, in biochemical and histological examinations of liver, db-EtOH showed significantly higher content of triglycerides in association with vacuolization change, possibly due to fat accumulation in the liver. Conclusions: Low concentration of ethanol aggravated fatty liver in db mice, in regardless of aggravation of glycemic control. This may indicate that fatty liver is a significant marker to consider alcohol intake in patients with diabetes. |
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| 内容記述言語 | en | |||||
| 収録雑誌名 |
ja : 鹿児島大学医学雑誌 en : Medical journal of Kagoshima University 巻 69, p. 1-8, 発行日 2017-12 |
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| 作成日 | ||||||
| 日付 | 2017-07 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 03685063 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AN00040104 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 公開者・出版者 | ||||||
| 出版者 | Kagoshima University | |||||
| 出版者言語 | en | |||||
