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食道扁平上皮癌患者においてSOX9の発現は予後に関連している
http://hdl.handle.net/10232/00032118
http://hdl.handle.net/10232/0003211842e3d1aa-b2d3-477e-98db-295b87d1ecab
| 名前 / ファイル | ライセンス | アクション |
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Diss_肥後_直倫_ISK668_2022 (195.0 kB)
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Abstract_肥後_直倫_4512810345_2022 (33.5 kB)
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Result_higo_Naotomo_isk_668 (140.7 kB)
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Comments_higo_Naotomo_isk_668 (74.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-09-20 | |||||
| タイトル | ||||||
| タイトル | Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma | |||||
| タイトル言語 | en | |||||
| タイトル | ||||||
| タイトル | 食道扁平上皮癌患者においてSOX9の発現は予後に関連している | |||||
| タイトル言語 | ja | |||||
| 著者 |
肥後, 直倫
× 肥後, 直倫 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | SOX9 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | oesophageal cancer | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prognosis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. Materials and Methods: SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas. Results: SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not. Conclusion: SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor. Oesophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract (1). There have been many studies of the effects of various biological factors on the malignant potential of ESCC. Sex-determining region Y-box 9 (SOX9) is an important transcriptional factor for the development and differentiation of cells and their organization (2). Recently, there have been reports of a correlation between SOX9 expression and clinical outcomes in some cancer types, including gastrointestinal tract cancer (3-9). The aims of this retrospective study were to examine the expression of SOX9 protein in surgical specimens from patients with ESCC treated with radical surgery and to evaluate whether such expression is useful for predicting their outcome. NAOTOMO HIGO, HIROSHI OKUMURA, YASUTO UCHIKADO, ITARU OMOTO, KEN SASAKI, YOSHIAKI KITA, DESAKI RYOSUKE, MASAHIRO NODA, TETSUHIRO OWAKI, SUMIYA ISHIGAMI and SHOJI NATSUGOE Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma In Vivo 32: 835-838 (2018) https://doi.org/10.21873/invivo.11316 |
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| 内容記述言語 | en | |||||
| 作成日 | ||||||
| 日付 | 2022-09-08 | |||||
| 日付タイプ | Collected | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| ファイル（説明） | ||||||
| 内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
| 公開者・出版者 | ||||||
| 出版者 | International Institute of Anticancer Research | |||||
| 出版者言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 出版者言語 | ja | |||||
| 備考 | ||||||
| 備考言語 | ja | |||||
| 備考 | 【指導教員:大塚隆生】 | |||||
| date.appl | ||||||
| appl | 【学位申請日】2021-09-01 | |||||
| 学位名 | ||||||
| 学位名の言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位名 | ||||||
| 学位名の言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Science | |||||
| 学位授与機関名 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17701 | |||||
| 学位授与機関名の言語 | ja | |||||
| 学位授与機関名 | 鹿児島大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2022-09-13 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲総研第668号 | |||||
