{"_buckets": {"deposit": "3e714e15-250e-441a-8698-b6988e089fb1"}, "_deposit": {"created_by": 3, "id": "2454", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2454"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00002454", "sets": ["5161", "59"]}, "author_link": ["119084", "119085"], "item_7_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Epstein-Barrウイルス（EBV）関連胃がんにおけるEBV-BARF1遺伝子配列の変異"}]}, "item_7_biblio_info_5": {"attribute_name": "収録雑誌名", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "27", "bibliographicPageStart": "19", "bibliographicVolumeNumber": "61", "bibliographic_titles": [{"bibliographic_title": "鹿児島大学医学雑誌"}, {"bibliographic_title": "Medical journal of Kagoshima University", "bibliographic_titleLang": "en"}]}]}, "item_7_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2009-09-01"}]}, "item_7_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "Epstein-Barr virus (EBV)-encoded BARF1 is suspected to play an important role in development of EBV-associated gastric carcinoma (EBV-GC). The present study examined the sequence variation of BARF1-promoter region (‒488/+87) of EBV genomes detected in 22 Colombian and 17 Japanese EBV-GCs. In addition, the EBV genomes in throat washing samples from 11 Colombian and 9 Japanese healthy donors (controls) were examined. All the EBV strains isolated from healthy donors had the same BARF1-promoter-region sequence as the prototype strain B95-8. In contrast, the EBV-GCs showed the following 8 point mutations in comparison with the B95-8 strain: G→C at ‒367 in 2 Colombian EBV-GC cases; T→A at ‒356 in 1 Colombian EBV-GC case; C→G at +15 in 1 Colombian EBV-GC case; C→T at +24 in 5 Colombian EBVGC cases; T→G at +26 in 3 Colombian EBV-GC cases; T→C at +29 in 7 and 2 Colombian and Japanese EBV-GC cases, respectively; T→A at +44 in 5 Colombian EBV-GC cases; and G→A at +46 in 1 Japanese EBV-GC case. The observed casecontrol difference at position +29 was statistically significant (p=0.022, Fisher’s exact test). Although the frequency of this point mutation in Colombian EBV-GCs was higher than that in Japanese EBV-GCs, the difference was not statistically significant (p=0.251). In summary, the present study, examining the BARF1-promoter region of EBV genomes detected in 39 EBV-GCs and throat washing specimens from 20 healthy donors, found a statistically significant increase of the point mutation of T→C at position +29 in EBV-GC. Further studies seem warranted to clarify the etiological significance of this finding.", "subitem_description_type": "Other"}]}, "item_7_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "119085", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "オルドネス, パウラ"}]}]}, "item_7_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_7_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0368-5063", "subitem_source_identifier_type": "ISSN"}]}, "item_7_source_id_9": {"attribute_name": "NII書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00040104", "subitem_source_identifier_type": "NCID"}]}, "item_7_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "498", "subitem_subject_scheme": "NDC"}]}, "item_7_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_7_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_7_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Departmental Bulletin Paper"}]}, "item_7_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ORDONEZ, Paula"}], "nameIdentifiers": [{"nameIdentifier": "119084", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "AN00040104_v61n2_p19-27.pdf", "filesize": [{"value": "253.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 253600.0, "url": {"label": "AN00040104_v61n2_p19-27.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/2454/files/AN00040104_v61n2_p19-27.pdf"}, "version_id": "188144e2-d7fa-49fd-9b34-2ed7801005a0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Epstein-Barr virus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gastric carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BARF1 promoter", "subitem_subject_scheme": "Other"}, {"subitem_subject": "viral oncogene", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma"}]}, "item_type_id": "7", "owner": "3", "path": ["59", "5161"], "permalink_uri": "http://hdl.handle.net/10232/14440", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-07-03"}, "publish_date": "2012-07-03", "publish_status": "0", "recid": "2454", "relation": {}, "relation_version_is_last": true, "title": ["Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma"], "weko_shared_id": 3}