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mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions
http://hdl.handle.net/10232/25578
http://hdl.handle.net/10232/255784434be9d-ff32-463c-8dd2-d01c106bf08a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
srep03230.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-11-05 | |||||
| タイトル | ||||||
| タイトル | mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions | |||||
| タイトル言語 | en | |||||
| 著者 |
松原, 修一郎
× 松原, 修一郎× 丁, 強× 宮崎, 優美× 桑畑, 太作× 政, 幸一郎× 高尾, 尊身 |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Pancreatic cancer is characterized by near-universal mutations in KRAS. The mammalian target of rapamycin (mTOR), which functions downstream of RAS, has divergent effects on stem cells. In the present study, we investigated the significance of the mTOR pathway in maintaining the properties of pancreatic cancer stem cells. The mTOR inhibitor, rapamycin, reduced the viability of CD133+ pancreatic cancer cells and sphere formation which is an index of self-renewal of stem-like cells, indicating that the mTOR pathway functions to maintain cancer stem-like cells. Further, rapamycin had different effects on CD133+ cells compared to cyclopamine which is an inhibitor of the Hedgehog pathway. Thus, the mTOR pathway has a distinct role although both pathways maintain pancreatic cancer stem cells. Therefore, mTOR might be a promising target to eliminate pancreatic cancer stem cells. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Scientific Reports 巻 3, p. 1-10, 発行日 2013 |
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| 作成日 | ||||||
| 日付 | 2013-11-15 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| ISSN | 20452322 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1038/srep03230 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | http://www.nature.com/articles/srep03230 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| 公開者・出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 出版者言語 | en | |||||
