{"_buckets": {"deposit": "a17380a1-bdfd-4162-bfea-651cfbfc9408"}, "_deposit": {"created_by": 3, "id": "6020", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "6020"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00006020", "sets": ["83"]}, "author_link": ["4647", "74383", "74382"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "New anti-glioma treatment strategy by clarification of dominat Wnt/Frezzled massage"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "Wnt/Frizzledケイ シュヨウ メッセージ ケイロ タンサク ニヨル アタラシイ コウグリオーマ センリャク"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2014-08-13"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23592135　研究代表者：平野宏文（鹿児島大学医学部・歯学部附属病院・講師）", "subitem_description_type": "Other"}, {"subitem_description": "予後不良疾患である膠芽腫は周囲組織へ浸潤する時MMPが関与しており、分泌性糖タンパク質であるWntは、受容体Fzd, Ror2, Rykと結合する。先行論文で膠芽腫ではWnt-5aが高発現し、MMP-2を上昇させることを報告した。今回はMMP-2を介した細胞浸潤は受容体Rykを介していることを発見した。また悪性度とFzd2, Rykの発現が相関することが分かった（J Biochem 2014）。膠芽腫ではFzd2とFzd6の高発現が予後不良因子であることも報告した（Brain Tumor Pathol 2013）", "subitem_description_type": "Other"}, {"subitem_description": "Glioblastoma, one of the most malignant brain tumors, invade surrounding brain by expression of MMPs. Wnts, secretory proteins bind to their receptors, Fzd, Ror2, and Ryk. We previously reported that Wnt-5a was highly expressed and it up-regulated MMP-2 in glioblastoma. In this work, we revealed that tumor cell invasion by MMP-2 was achieved via receptor Ryk, and the degree of histological malignancy correlated with expression of Fzd2 and Ryk (J Biochem 2014,  doi:  10.1093/jb/mvu 015). In another analysis, we reported that high expression of Fzd2 and Fzd6 was poor prognostic factor in glioblastoma patients (Brain Tumor Pathol 2013, 10.1007/s10014-013-0153-1).", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "74382", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ヒラノ, ヒロフミ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "74383", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "HIRANO, Hirofumi"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "493", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "23592135"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "平野, 宏文"}], "nameIdentifiers": [{"nameIdentifier": "4647", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000000264416", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "23592135_hirano_hirofumi_revised.pdf", "filesize": [{"value": "550.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 550200.0, "url": {"label": "23592135_hirano_hirofumi_revised.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/6020/files/23592135_hirano_hirofumi_revised.pdf"}, "version_id": "81fc50cd-47f2-4f74-9fa8-1b9724460dae"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "glioblastoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Wnt-5a", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MMP-2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fzd2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fdz6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ryk", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ror2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "invasion", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "Wnt/Frizzled系主要メッセージ経路探索による新しい抗グリオーマ戦略", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Wnt/Frizzled系主要メッセージ経路探索による新しい抗グリオーマ戦略"}]}, "item_type_id": "8", "owner": "3", "path": ["83"], "permalink_uri": "http://hdl.handle.net/10232/24319", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-05-26"}, "publish_date": "2015-05-26", "publish_status": "0", "recid": "6020", "relation": {}, "relation_version_is_last": true, "title": ["Wnt/Frizzled系主要メッセージ経路探索による新しい抗グリオーマ戦略"], "weko_shared_id": 3}