Item type |
紀要論文 / Departmental Bulletin Paper(1) |
公開日 |
2007-04-24 |
タイトル |
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|
タイトル |
Perchloric acid-soluble protein is accumulated in nuclei by ER-stressors |
著者 |
KANOUCHI, Hiroaki
TAGA, Masaki
MATSUMOTO, Mitsuharu
OKA, Tatsuzo
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言語 |
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言語 |
eng |
キーワード |
|
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主題Scheme |
Other |
|
主題 |
perchloric acid-soluble protein |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
p14.5 |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
μ-calpain |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
endoplasmic reticulum |
キーワード |
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主題Scheme |
Other |
|
主題 |
ER-stress |
キーワード |
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|
主題Scheme |
Other |
|
主題 |
thapsigargin |
資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
要約(Abstract) |
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内容記述タイプ |
Other |
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内容記述 |
Perchloric acid-soluble protein (PSP) is highly conserved during evolution from bacteria to mammals. Although PSP has been recognized as an inhibitor of translation and a μ-calpain activator, its precise biological role has not yet been elucidated. Because the μ-calpain has been reported to act as an inducer of apoptosis in endoplasmic reticulum (ER)-stressed cells, we speculated that PSP might be associated with ER-stress. In this study, we used immunoelectron microscopy to demonstrate that PSP locates on the ER membrane. Moreover, various ER-stressors (thapsigargin, A23187, tunicamycin, brefeldin A and cisplatin) provoked dramatic change in localization of PSP from ER to nuclei. These results suggest that PSP is a novel ER-stress associated protein and may induce attenuation of translation and/or apoptosis in ER-stressed cells. |
収録雑誌名 |
Memoirs of the Faculty of Agriculture, Kagoshima University
巻 40,
p. 17-24
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作成日 |
|
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日付 |
2005-02-20 |
ISSN |
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収録物識別子タイプ |
ISSN |
|
ISSN |
04530853 |
NII書誌ID(雑誌) |
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収録物識別子タイプ |
NCID |
|
NC ID |
AA00732376 |
出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
NDC |
|
|
主題Scheme |
NDC |
|
主題 |
610 |
NIIsubject |
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|
主題Scheme |
Other |
|
主題 |
農学 |
公開者・出版者 |
|
|
出版者 |
鹿児島大学 |
公開者よみ |
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|
公開者よみ |
カゴシマ ダイガク |
公開者別名 |
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|
公開者別名 |
Kagoshima University |