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Perchloric acid-soluble protein is accumulated in nuclei by ER-stressors
http://hdl.handle.net/10232/2835
http://hdl.handle.net/10232/283525dcd061-4e55-4f81-9888-79a9aa4ce76f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004161864.pdf (704.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-04-24 | |||||
| タイトル | ||||||
| タイトル | Perchloric acid-soluble protein is accumulated in nuclei by ER-stressors | |||||
| 著者 |
KANOUCHI, Hiroaki
× KANOUCHI, Hiroaki× TAGA, Masaki× MATSUMOTO, Mitsuharu× OKA, Tatsuzo |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | perchloric acid-soluble protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p14.5 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | μ-calpain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endoplasmic reticulum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ER-stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | thapsigargin | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Perchloric acid-soluble protein (PSP) is highly conserved during evolution from bacteria to mammals. Although PSP has been recognized as an inhibitor of translation and a μ-calpain activator, its precise biological role has not yet been elucidated. Because the μ-calpain has been reported to act as an inducer of apoptosis in endoplasmic reticulum (ER)-stressed cells, we speculated that PSP might be associated with ER-stress. In this study, we used immunoelectron microscopy to demonstrate that PSP locates on the ER membrane. Moreover, various ER-stressors (thapsigargin, A23187, tunicamycin, brefeldin A and cisplatin) provoked dramatic change in localization of PSP from ER to nuclei. These results suggest that PSP is a novel ER-stress associated protein and may induce attenuation of translation and/or apoptosis in ER-stressed cells. | |||||
| 収録雑誌名 |
Memoirs of the Faculty of Agriculture, Kagoshima University 巻 40, p. 17-24 |
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| 作成日 | ||||||
| 日付 | 2005-02-20 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| ISSN | 04530853 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA00732376 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 610 | |||||
| NIIsubject | ||||||
| 主題Scheme | Other | |||||
| 主題 | 農学 | |||||
| 公開者・出版者 | ||||||
| 出版者 | 鹿児島大学 | |||||
| 公開者よみ | ||||||
| 公開者よみ | カゴシマ ダイガク | |||||
| 公開者別名 | ||||||
| 公開者別名 | Kagoshima University | |||||
