Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2010-04-13 |
タイトル |
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タイトル言語 |
en |
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タイトル |
Metachronous occurrence of gastric T-cell rich B-cell lymphoma and nodal T-cell lymphoma in a HTLV-1 carrier |
著者 |
Hasui, Kazuhisa
Shirahama, Hiroshi
Sueyoshi, Kazunobu
Sato, Eiichi
Imakuma, Mitsuru
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言語 |
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言語 |
eng |
キーワード |
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主題言語 |
en |
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主題Scheme |
Other |
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主題 |
HTLV-1 |
キーワード |
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主題言語 |
en |
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主題Scheme |
Other |
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主題 |
malignant lymphoma |
キーワード |
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主題言語 |
en |
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主題Scheme |
Other |
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主題 |
pathology |
キーワード |
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主題言語 |
en |
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主題Scheme |
Other |
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主題 |
histochemistry |
キーワード |
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主題言語 |
en |
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主題Scheme |
Other |
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主題 |
polymerase chain reaction |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
要約(Abstract) |
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内容記述タイプ |
Other |
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内容記述 |
ln a HTLV-1 carrier Japanese man gastric T cell-rich B cell lymphoma occurred at 67 years of age and nodal T cell malignant lymphoma appeared at 72 years of age. The gastric T-cell rich B-cell Iymphoma formed an ulcerated tumor in the posterior wall of the body, involving up to the serosa and regional lymph nodes. A few lymphoma cells had cytoplasmic monoclonal κ and λ type immunoglobulin. Signals of HTLV-l pX Tax DNA sequence and stains of three antibodies against HTLV-1-encoded proteins (gp46env, p40tax and p19gag) in some lymphoma cells suggested that this gastric lymphoma was a HTLV-1-related case. Six years later, large cell type T-cell malignant lymphoma occurred in left inguinal lymph node. Many S100+ dendritic cells and ysozyme+ cells were intermingling among the lymphoma cells. Some epithelioid cells among the lymphoma cells showed weak stains of the three antibodies against HTLV-l-encoded proteins. The PCR analysis showed oligoclonal rearrangement bands of TCRβ gene in the agar-gel electrophoresis. After three months' follow-up without chemotherapy, recurrent swelling of left inguinal lymph node and splenomegaly appeared. After chemotherapy the biopsied left inguinal lymph node showed necrosis and residual T cell malignant lymphoma. The uncommon features such as many T cells in the gastric lymphoma and many S100+ cells, many lysozyme+ cells and oligoclonal rearrangement of TCRβ gene in the nodal T-cell lymphoma might be induced by HTLV-1 infection. The patient has survived without any complaints. The HTLV-l-related lymphoid malignancies other than adult T-cell leukemia/lymphoma would be not-aggressive and might be the diseases in the microenvironment under the immunocompromised state in HTLV-1 carrier. |
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内容記述言語 |
en |
収録雑誌名 |
en : Dendritic cells
巻 6,
p. 14-21,
発行日 1996-01-01
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作成日 |
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日付 |
1996-01-01 |
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日付タイプ |
Issued |
NII書誌ID(雑誌) |
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収録物識別子タイプ |
NCID |
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NC ID |
AA11039557 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
NDC |
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主題Scheme |
NDC |
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主題 |
490 |
NIIsubject |
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主題言語 |
ja |
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主題Scheme |
Other |
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主題 |
医学 |
公開者・出版者 |
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出版者言語 |
ja |
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出版者 |
日本樹状細胞研究会 |
公開者・出版者 |
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出版者言語 |
en |
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出版者 |
Japanese Dendritic Cells Society |