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歯周病とプロスタグランジン
http://hdl.handle.net/10232/4861
http://hdl.handle.net/10232/4861f8b1ae14-c582-425a-81ce-324c97d12d1f
名前 / ファイル | ライセンス | アクション |
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28-11.pdf (129.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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公開日 | 2015-01-13 | |||||||||
タイトル | ||||||||||
タイトル言語 | ja | |||||||||
タイトル | 歯周病とプロスタグランジン | |||||||||
タイトル | ||||||||||
タイトル言語 | en | |||||||||
タイトル | Periodontal diseases and prostaglandins | |||||||||
著者 |
野口, 和行
× 野口, 和行
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言語 | ||||||||||
言語 | jpn | |||||||||
キーワード | ||||||||||
主題言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | periodontal disease | |||||||||
キーワード | ||||||||||
主題言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | prostanoid | |||||||||
キーワード | ||||||||||
主題言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | prostaglandin E2 | |||||||||
キーワード | ||||||||||
主題言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cyclooxygenase | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | departmental bulletin paper | |||||||||
要約(Abstract) | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | It is clear that prostanoids including prostaglandin E2 (PGE2) are involved in the pathogenesis ofperiodontal diseases, because a lot of studies have indicated that in animal models and humans traditional nonsteroidal anti-inflammatory drugs inhibit progression of the diseases. Recent researches have shown that cyclooxygenase-2, which is an inducible prostaglandin-endoperoxide synthase in response to proinflammatory molecules, plays a crucial role in prostaglandin production in periodontal lesions. Monocytes/macrophages, gingival fibroblasts and periodontal ligament cells can produce PGE2 via cyclooxygense-2 after stimulation with interleukin-1, tumor necrosis factor a and lipopolysaccharides. PGE2 exerts a variety of pro-inflammatory actions including osteoclast formation. Furthermore, selective cyclooxygenase-2 inhibitors are as efficacious as traditional nonsteroidal anti-inflammatory drugs for inhibition of progression of periodontal diseases in animal models. Therefore, cyclooxygenase-2 inhibitors may be effective for a host modulatory therapy of periodontal diseases, but clinical studies with great care are necessary to prove it, based on the understanding of the advantages and disadvantages of cyclooxygenase-2 inhibitors. | |||||||||
内容記述言語 | en | |||||||||
収録雑誌名 |
ja : 鹿児島大学歯学部紀要 巻 28, p. 39-48, 発行日 2008-03-26 |
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作成日 | ||||||||||
日付 | 2008-03-26 | |||||||||
日付タイプ | Issued | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
ISSN | 0389-7834 | |||||||||
NII書誌ID(雑誌) | ||||||||||
収録物識別子タイプ | NCID | |||||||||
NC ID | AN0035442X | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
NDC | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 497 | |||||||||
公開者・出版者 | ||||||||||
出版者言語 | ja | |||||||||
出版者 | 鹿児島大学 | |||||||||
公開者・出版者 | ||||||||||
出版者言語 | en | |||||||||
出版者 | Kagoshima University |